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Neuropsychiatric symptoms in untreated Parkinson’s disease

Neuropsychiatric and cognitive symptoms are common in Parkinson’s disease (PD) and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS) in PD are various and are attributed to pathologic changes within multiple brain reg...

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Autores principales: Szatmari, Szabolcs, Illigens, Ben Min-Woo, Siepmann, Timo, Pinter, Alexandra, Takats, Annamaria, Bereczki, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360401/
https://www.ncbi.nlm.nih.gov/pubmed/28352181
http://dx.doi.org/10.2147/NDT.S130997
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author Szatmari, Szabolcs
Illigens, Ben Min-Woo
Siepmann, Timo
Pinter, Alexandra
Takats, Annamaria
Bereczki, Daniel
author_facet Szatmari, Szabolcs
Illigens, Ben Min-Woo
Siepmann, Timo
Pinter, Alexandra
Takats, Annamaria
Bereczki, Daniel
author_sort Szatmari, Szabolcs
collection PubMed
description Neuropsychiatric and cognitive symptoms are common in Parkinson’s disease (PD) and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS) in PD are various and are attributed to pathologic changes within multiple brain regions, to psychological stress, and to adverse effects of dopamine replacement therapy. Sleep disorders and mood symptoms such as apathy, depression, and anxiety may antedate the development of motor symptoms by years, while other NPS such as impulse control disorders, psychosis, and cognitive impairment are more common in later stages of the disease. Few studies report on NPS in the early, untreated phase of PD. We reviewed the current literature on NPS in PD with a focus on the early, drug-naive stages of PD. Among these early disease stages, premotor and early motor phases were separately addressed in our review, highlighting the underlying pathophysiological mechanisms as well as epidemiological characteristics, clinical features, risk factors, and available techniques of clinical assessment.
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spelling pubmed-53604012017-03-28 Neuropsychiatric symptoms in untreated Parkinson’s disease Szatmari, Szabolcs Illigens, Ben Min-Woo Siepmann, Timo Pinter, Alexandra Takats, Annamaria Bereczki, Daniel Neuropsychiatr Dis Treat Review Neuropsychiatric and cognitive symptoms are common in Parkinson’s disease (PD) and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS) in PD are various and are attributed to pathologic changes within multiple brain regions, to psychological stress, and to adverse effects of dopamine replacement therapy. Sleep disorders and mood symptoms such as apathy, depression, and anxiety may antedate the development of motor symptoms by years, while other NPS such as impulse control disorders, psychosis, and cognitive impairment are more common in later stages of the disease. Few studies report on NPS in the early, untreated phase of PD. We reviewed the current literature on NPS in PD with a focus on the early, drug-naive stages of PD. Among these early disease stages, premotor and early motor phases were separately addressed in our review, highlighting the underlying pathophysiological mechanisms as well as epidemiological characteristics, clinical features, risk factors, and available techniques of clinical assessment. Dove Medical Press 2017-03-16 /pmc/articles/PMC5360401/ /pubmed/28352181 http://dx.doi.org/10.2147/NDT.S130997 Text en © 2017 Szatmari et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Szatmari, Szabolcs
Illigens, Ben Min-Woo
Siepmann, Timo
Pinter, Alexandra
Takats, Annamaria
Bereczki, Daniel
Neuropsychiatric symptoms in untreated Parkinson’s disease
title Neuropsychiatric symptoms in untreated Parkinson’s disease
title_full Neuropsychiatric symptoms in untreated Parkinson’s disease
title_fullStr Neuropsychiatric symptoms in untreated Parkinson’s disease
title_full_unstemmed Neuropsychiatric symptoms in untreated Parkinson’s disease
title_short Neuropsychiatric symptoms in untreated Parkinson’s disease
title_sort neuropsychiatric symptoms in untreated parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360401/
https://www.ncbi.nlm.nih.gov/pubmed/28352181
http://dx.doi.org/10.2147/NDT.S130997
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