YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

Branching morphogenesis is a fundamental program for tissue patterning. We show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Chuwen, Yao, Erica, Zhang, Kuan, Jiang, Xuan, Croll, Stacey, Thompson-Peer, Katherine, Chuang, Pao-Tien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360446/
https://www.ncbi.nlm.nih.gov/pubmed/28323616
http://dx.doi.org/10.7554/eLife.21130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360446/
https://www.ncbi.nlm.nih.gov/pubmed/28323616
http://dx.doi.org/10.7554/eLife.21130

Ejemplares similares