Cargando…
Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice
The adaptive immune system is dependent on functionally distinct lineages of T cell antigen receptor αβ-expressing T cells that differentiate from a common progenitor in the thymus. CD4(+)CD8(+) progenitor thymocytes undergo selection following interaction with MHC class I and class II molecules bea...
Autores principales: | Issuree, Priya D. A., Ng, Charles P., Littman, Dan R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360760/ https://www.ncbi.nlm.nih.gov/pubmed/28382035 http://dx.doi.org/10.3389/fimmu.2017.00291 |
Ejemplares similares
-
Regulation of DNA methylation dictates Cd4 gene expression during development of helper and cytotoxic T cell lineages
por: Sellars, MacLean, et al.
Publicado: (2015) -
HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4(+)CD8(+) thymocytes for CD4-lineage commitment
por: Philips, Rachael Laura, et al.
Publicado: (2019) -
Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
por: Issuree, Priya D., et al.
Publicado: (2018) -
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
por: Karimi, Mohammad M., et al.
Publicado: (2021) -
Centromeric Repositioning of Coreceptor Loci Predicts Their Stable Silencing and the CD4/CD8 Lineage Choice
por: Merkenschlager, Matthias, et al.
Publicado: (2004)