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Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorders characterized by impaired social interactions, communication deficits, and repetitive behavior. Although the mechanisms underlying its etiology and manifestations are poorly understood, several lines of evidence from r...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Singapore
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360847/ https://www.ncbi.nlm.nih.gov/pubmed/28283809 http://dx.doi.org/10.1007/s12264-017-0120-7 |
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author | Zhang, Rong Zhang, Hong-Feng Han, Ji-Sheng Han, Song-Ping |
author_facet | Zhang, Rong Zhang, Hong-Feng Han, Ji-Sheng Han, Song-Ping |
author_sort | Zhang, Rong |
collection | PubMed |
description | Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorders characterized by impaired social interactions, communication deficits, and repetitive behavior. Although the mechanisms underlying its etiology and manifestations are poorly understood, several lines of evidence from rodent and human studies suggest involvement of the evolutionarily highly-conserved oxytocin (OXT) and arginine-vasopressin (AVP), as these neuropeptides modulate various aspects of mammalian social behavior. As far as we know, there is no comprehensive review of the roles of the OXT and AVP systems in the development of ASD from the genetic aspect. In this review, we summarize the current knowledge regarding associations between ASD and single-nucleotide variants of the human OXT-AVP pathway genes OXT, AVP, AVP receptor 1a (AVPR1a), OXT receptor (OXTR), the oxytocinase/vasopressinase (LNPEP), and ADP-ribosyl cyclase (CD38). |
format | Online Article Text |
id | pubmed-5360847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-53608472017-04-04 Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders Zhang, Rong Zhang, Hong-Feng Han, Ji-Sheng Han, Song-Ping Neurosci Bull Review Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorders characterized by impaired social interactions, communication deficits, and repetitive behavior. Although the mechanisms underlying its etiology and manifestations are poorly understood, several lines of evidence from rodent and human studies suggest involvement of the evolutionarily highly-conserved oxytocin (OXT) and arginine-vasopressin (AVP), as these neuropeptides modulate various aspects of mammalian social behavior. As far as we know, there is no comprehensive review of the roles of the OXT and AVP systems in the development of ASD from the genetic aspect. In this review, we summarize the current knowledge regarding associations between ASD and single-nucleotide variants of the human OXT-AVP pathway genes OXT, AVP, AVP receptor 1a (AVPR1a), OXT receptor (OXTR), the oxytocinase/vasopressinase (LNPEP), and ADP-ribosyl cyclase (CD38). Springer Singapore 2017-03-10 /pmc/articles/PMC5360847/ /pubmed/28283809 http://dx.doi.org/10.1007/s12264-017-0120-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Zhang, Rong Zhang, Hong-Feng Han, Ji-Sheng Han, Song-Ping Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders |
title | Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders |
title_full | Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders |
title_fullStr | Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders |
title_full_unstemmed | Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders |
title_short | Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders |
title_sort | genes related to oxytocin and arginine-vasopressin pathways: associations with autism spectrum disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360847/ https://www.ncbi.nlm.nih.gov/pubmed/28283809 http://dx.doi.org/10.1007/s12264-017-0120-7 |
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