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Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice
Refractory wound is a dreaded complication of diabetes and is highly correlated with EPC dysfunction caused by hyperglycemia. Acarbose is a widely used oral glucose-lowering drug exclusively for T2DM. Previous studies have suggested the beneficial effect of acarbose on improving endothelial dysfunct...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360971/ https://www.ncbi.nlm.nih.gov/pubmed/28373902 http://dx.doi.org/10.1155/2017/7809581 |
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author | Han, Xue Deng, Yaping Yu, Jiawen Sun, Yuannan Ren, Guofei Cai, Jian Zhu, Jianjun Jiang, Guojun |
author_facet | Han, Xue Deng, Yaping Yu, Jiawen Sun, Yuannan Ren, Guofei Cai, Jian Zhu, Jianjun Jiang, Guojun |
author_sort | Han, Xue |
collection | PubMed |
description | Refractory wound is a dreaded complication of diabetes and is highly correlated with EPC dysfunction caused by hyperglycemia. Acarbose is a widely used oral glucose-lowering drug exclusively for T2DM. Previous studies have suggested the beneficial effect of acarbose on improving endothelial dysfunction in patients with T2DM. However, no data have been reported on the beneficial efficacy of acarbose in wound healing impairment caused by diabetes. We herein investigated whether acarbose could improve wound healing in T2DM db/db mice and the possible mechanisms involved. Acarbose hastened wound healing and enhanced angiogenesis, accompanied by increased circulating EPC number in db/db mice. In vitro, a reversed BM-EPC dysfunction was observed after the administration of acarbose in db/db mice, as reflected by tube formation assay. In addition, a significantly increased NO production was also witnessed in BM-EPCs from acarbose treated db/db mice, with decreased O(2) levels. Akt inhibitor could abolish the beneficial effect of acarbose on high glucose induced EPC dysfunction in vitro, accompanied by reduced eNOS activation. Acarbose displayed potential effect in promoting wound healing and improving angiogenesis in T2DM mice, which was possibly related to the Akt/eNOS signaling pathway. |
format | Online Article Text |
id | pubmed-5360971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-53609712017-04-03 Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice Han, Xue Deng, Yaping Yu, Jiawen Sun, Yuannan Ren, Guofei Cai, Jian Zhu, Jianjun Jiang, Guojun Oxid Med Cell Longev Research Article Refractory wound is a dreaded complication of diabetes and is highly correlated with EPC dysfunction caused by hyperglycemia. Acarbose is a widely used oral glucose-lowering drug exclusively for T2DM. Previous studies have suggested the beneficial effect of acarbose on improving endothelial dysfunction in patients with T2DM. However, no data have been reported on the beneficial efficacy of acarbose in wound healing impairment caused by diabetes. We herein investigated whether acarbose could improve wound healing in T2DM db/db mice and the possible mechanisms involved. Acarbose hastened wound healing and enhanced angiogenesis, accompanied by increased circulating EPC number in db/db mice. In vitro, a reversed BM-EPC dysfunction was observed after the administration of acarbose in db/db mice, as reflected by tube formation assay. In addition, a significantly increased NO production was also witnessed in BM-EPCs from acarbose treated db/db mice, with decreased O(2) levels. Akt inhibitor could abolish the beneficial effect of acarbose on high glucose induced EPC dysfunction in vitro, accompanied by reduced eNOS activation. Acarbose displayed potential effect in promoting wound healing and improving angiogenesis in T2DM mice, which was possibly related to the Akt/eNOS signaling pathway. Hindawi 2017 2017-03-08 /pmc/articles/PMC5360971/ /pubmed/28373902 http://dx.doi.org/10.1155/2017/7809581 Text en Copyright © 2017 Xue Han et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Han, Xue Deng, Yaping Yu, Jiawen Sun, Yuannan Ren, Guofei Cai, Jian Zhu, Jianjun Jiang, Guojun Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice |
title | Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice |
title_full | Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice |
title_fullStr | Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice |
title_full_unstemmed | Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice |
title_short | Acarbose Accelerates Wound Healing via Akt/eNOS Signaling in db/db Mice |
title_sort | acarbose accelerates wound healing via akt/enos signaling in db/db mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360971/ https://www.ncbi.nlm.nih.gov/pubmed/28373902 http://dx.doi.org/10.1155/2017/7809581 |
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