Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways

Akirin2, a novel nuclear factor, plays an important role in myogenesis. To investigate the role of Akirin2 in proliferation and differentiation of porcine skeletal muscle satellite cells, Akirin2 overexpression and Akirin2 silence technologies were employed. Our results showed that overexpression of...

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Autores principales: Chen, Xiaoling, Luo, Yanliu, Huang, Zhiqing, Jia, Gang, Liu, Guangmang, Zhao, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361102/
https://www.ncbi.nlm.nih.gov/pubmed/28327665
http://dx.doi.org/10.1038/srep45156
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author Chen, Xiaoling
Luo, Yanliu
Huang, Zhiqing
Jia, Gang
Liu, Guangmang
Zhao, Hua
author_facet Chen, Xiaoling
Luo, Yanliu
Huang, Zhiqing
Jia, Gang
Liu, Guangmang
Zhao, Hua
author_sort Chen, Xiaoling
collection PubMed
description Akirin2, a novel nuclear factor, plays an important role in myogenesis. To investigate the role of Akirin2 in proliferation and differentiation of porcine skeletal muscle satellite cells, Akirin2 overexpression and Akirin2 silence technologies were employed. Our results showed that overexpression of Akirin2 markedly enhanced the proliferation and differentiation of porcine skeletal muscle satellite cells, whereas silencing of Akirin2 got the opposite results. Furthermore, our results showed that Akirin2 affected proliferation and differentiation of porcine skeletal muscle satellite cells through extracellular-signal regulated kinase-1/2 (ERK1/2) and NFATc1 signaling pathways. These results indicate that Akirin2 can effectively promote skeletal muscle satellite cells proliferation and differentiation, acting through ERK1/2- and NFATc1-dependent mechanisms.
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spelling pubmed-53611022017-03-22 Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways Chen, Xiaoling Luo, Yanliu Huang, Zhiqing Jia, Gang Liu, Guangmang Zhao, Hua Sci Rep Article Akirin2, a novel nuclear factor, plays an important role in myogenesis. To investigate the role of Akirin2 in proliferation and differentiation of porcine skeletal muscle satellite cells, Akirin2 overexpression and Akirin2 silence technologies were employed. Our results showed that overexpression of Akirin2 markedly enhanced the proliferation and differentiation of porcine skeletal muscle satellite cells, whereas silencing of Akirin2 got the opposite results. Furthermore, our results showed that Akirin2 affected proliferation and differentiation of porcine skeletal muscle satellite cells through extracellular-signal regulated kinase-1/2 (ERK1/2) and NFATc1 signaling pathways. These results indicate that Akirin2 can effectively promote skeletal muscle satellite cells proliferation and differentiation, acting through ERK1/2- and NFATc1-dependent mechanisms. Nature Publishing Group 2017-03-22 /pmc/articles/PMC5361102/ /pubmed/28327665 http://dx.doi.org/10.1038/srep45156 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chen, Xiaoling
Luo, Yanliu
Huang, Zhiqing
Jia, Gang
Liu, Guangmang
Zhao, Hua
Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways
title Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways
title_full Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways
title_fullStr Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways
title_full_unstemmed Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways
title_short Akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via ERK1/2 and NFATc1 signaling pathways
title_sort akirin2 regulates proliferation and differentiation of porcine skeletal muscle satellite cells via erk1/2 and nfatc1 signaling pathways
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361102/
https://www.ncbi.nlm.nih.gov/pubmed/28327665
http://dx.doi.org/10.1038/srep45156
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