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Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal

A food scandal occurred in Taiwan in 2011 because the DEHP (di-2-ethylhexyl phthalate) had been intentionally used in food products. We assessed the daily intakes (DIs) and cumulative risk of phthalates in Taiwan’s general population after the scandal. The DIs of 6 phthalates, including di-n-butyl p...

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Autores principales: Chang, Jung-Wei, Lee, Ching-Chang, Pan, Wen-Harn, Chou, Wei-Chun, Huang, Han-Bin, Chiang, Hung-Che, Huang, Po-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361203/
https://www.ncbi.nlm.nih.gov/pubmed/28327585
http://dx.doi.org/10.1038/srep45009
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author Chang, Jung-Wei
Lee, Ching-Chang
Pan, Wen-Harn
Chou, Wei-Chun
Huang, Han-Bin
Chiang, Hung-Che
Huang, Po-Chin
author_facet Chang, Jung-Wei
Lee, Ching-Chang
Pan, Wen-Harn
Chou, Wei-Chun
Huang, Han-Bin
Chiang, Hung-Che
Huang, Po-Chin
author_sort Chang, Jung-Wei
collection PubMed
description A food scandal occurred in Taiwan in 2011 because the DEHP (di-2-ethylhexyl phthalate) had been intentionally used in food products. We assessed the daily intakes (DIs) and cumulative risk of phthalates in Taiwan’s general population after the scandal. The DIs of 6 phthalates, including di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), and DEHP, were evaluated using urinary phthalate metabolites. Hazard quotients of phthalates classified as affecting the reproductive (HQ(rep)) and hepatic (HQ(hep)) systems were assessed using cumulative approach. The creatinine-based model showed that the highest DI values in children 7-to 12- years-old were for DEHP (males: median: 4.79 μg/kg bw/d; females: median: 2.62 μg/kg bw/d). The 95(th) percentile (P95) of HQ(rep) values were all >1 in the 7- to 12-year-old and 18- to 40-year-old male groups. The P95 of HQ(hep) values were all >1 in the 7- to 18- year-old male groups. Most of the HQ(rep) was attributable to the HQs of DnBP and DiBP (53.9–84.7%), and DEHP contributed most to HQ(hep) (83.1–98.6%), which reveals that DnBP, DiBP and DEHP were the main risk of phthalate exposure for Taiwanese. Taiwan’s general population is widely exposed to DnBP, DiBP and DEHP, especially for young children.
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spelling pubmed-53612032017-03-24 Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal Chang, Jung-Wei Lee, Ching-Chang Pan, Wen-Harn Chou, Wei-Chun Huang, Han-Bin Chiang, Hung-Che Huang, Po-Chin Sci Rep Article A food scandal occurred in Taiwan in 2011 because the DEHP (di-2-ethylhexyl phthalate) had been intentionally used in food products. We assessed the daily intakes (DIs) and cumulative risk of phthalates in Taiwan’s general population after the scandal. The DIs of 6 phthalates, including di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), and DEHP, were evaluated using urinary phthalate metabolites. Hazard quotients of phthalates classified as affecting the reproductive (HQ(rep)) and hepatic (HQ(hep)) systems were assessed using cumulative approach. The creatinine-based model showed that the highest DI values in children 7-to 12- years-old were for DEHP (males: median: 4.79 μg/kg bw/d; females: median: 2.62 μg/kg bw/d). The 95(th) percentile (P95) of HQ(rep) values were all >1 in the 7- to 12-year-old and 18- to 40-year-old male groups. The P95 of HQ(hep) values were all >1 in the 7- to 18- year-old male groups. Most of the HQ(rep) was attributable to the HQs of DnBP and DiBP (53.9–84.7%), and DEHP contributed most to HQ(hep) (83.1–98.6%), which reveals that DnBP, DiBP and DEHP were the main risk of phthalate exposure for Taiwanese. Taiwan’s general population is widely exposed to DnBP, DiBP and DEHP, especially for young children. Nature Publishing Group 2017-03-22 /pmc/articles/PMC5361203/ /pubmed/28327585 http://dx.doi.org/10.1038/srep45009 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Chang, Jung-Wei
Lee, Ching-Chang
Pan, Wen-Harn
Chou, Wei-Chun
Huang, Han-Bin
Chiang, Hung-Che
Huang, Po-Chin
Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal
title Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal
title_full Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal
title_fullStr Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal
title_full_unstemmed Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal
title_short Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal
title_sort estimated daily intake and cumulative risk assessment of phthalates in the general taiwanese after the 2011 dehp food scandal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361203/
https://www.ncbi.nlm.nih.gov/pubmed/28327585
http://dx.doi.org/10.1038/srep45009
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