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Splicing Factor 1 Modulates Dietary Restriction and TORC1 Pathway Longevity in C. elegans

Ageing is driven by a loss of transcriptional and protein homeostasis(1–3) and is the key risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic dysfunction seen with age therefore have potential to reduce overall disease risk in the elderly. Pre-mRNA splicing is...

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Detalles Bibliográficos
Autores principales:	Heintz, Caroline, Doktor, Thomas Koed, Lanjuin, Anne, Escoubas, Caroline, Zhang, Yue, Weir, Heather J., Dutta, Sneha, Silva-García, Carlos Giovanni, Bruun, Gitte Hoffmann, Morantte, Ianessa, Hoxhaj, Gerta, Manning, Brendan D., Andresen, Brage S., Mair, William B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361225/ https://www.ncbi.nlm.nih.gov/pubmed/27919065 http://dx.doi.org/10.1038/nature20789

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