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Melatonin and human mitochondrial diseases

Mitochondrial dysfunction is one of the main causative factors in a wide variety of complications such as neurodegenerative disorders, ischemia/reperfusion, aging process, and septic shock. Decrease in respiratory complex activity, increase in free radical production, increase in mitochondrial synth...

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Autores principales: Sharafati-Chaleshtori, Reza, Shirzad, Hedayatollah, Rafieian-Kopaei, Mahmoud, Soltani, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361446/
https://www.ncbi.nlm.nih.gov/pubmed/28400824
http://dx.doi.org/10.4103/1735-1995.199092
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author Sharafati-Chaleshtori, Reza
Shirzad, Hedayatollah
Rafieian-Kopaei, Mahmoud
Soltani, Amin
author_facet Sharafati-Chaleshtori, Reza
Shirzad, Hedayatollah
Rafieian-Kopaei, Mahmoud
Soltani, Amin
author_sort Sharafati-Chaleshtori, Reza
collection PubMed
description Mitochondrial dysfunction is one of the main causative factors in a wide variety of complications such as neurodegenerative disorders, ischemia/reperfusion, aging process, and septic shock. Decrease in respiratory complex activity, increase in free radical production, increase in mitochondrial synthase activity, increase in nitric oxide production, and impair in electron transport system and/or mitochondrial permeability are considered as the main factors responsible for mitochondrial dysfunction. Melatonin, the pineal gland hormone, is selectively taken up by mitochondria and acts as a powerful antioxidant, regulating the mitochondrial bioenergetic function. Melatonin increases the permeability of membranes and is the stimulator of antioxidant enzymes including superoxide dismutase, glutathione peroxidase, glutathione reductase, and catalase. It also acts as an inhibitor of lipoxygenase. Melatonin can cause resistance to oxidation damage by fixing the microsomal membranes. Melatonin has been shown to retard aging and inhibit neurodegenerative disorders, ischemia/reperfusion, septic shock, diabetes, cancer, and other complications related to oxidative stress. The purpose of the current study, other than introducing melatonin, was to present the recent findings on clinical effects in diseases related to mitochondrial dysfunction including diabetes, cancer, gastrointestinal diseases, and diseases related to brain function.
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spelling pubmed-53614462017-04-11 Melatonin and human mitochondrial diseases Sharafati-Chaleshtori, Reza Shirzad, Hedayatollah Rafieian-Kopaei, Mahmoud Soltani, Amin J Res Med Sci Review Article Mitochondrial dysfunction is one of the main causative factors in a wide variety of complications such as neurodegenerative disorders, ischemia/reperfusion, aging process, and septic shock. Decrease in respiratory complex activity, increase in free radical production, increase in mitochondrial synthase activity, increase in nitric oxide production, and impair in electron transport system and/or mitochondrial permeability are considered as the main factors responsible for mitochondrial dysfunction. Melatonin, the pineal gland hormone, is selectively taken up by mitochondria and acts as a powerful antioxidant, regulating the mitochondrial bioenergetic function. Melatonin increases the permeability of membranes and is the stimulator of antioxidant enzymes including superoxide dismutase, glutathione peroxidase, glutathione reductase, and catalase. It also acts as an inhibitor of lipoxygenase. Melatonin can cause resistance to oxidation damage by fixing the microsomal membranes. Melatonin has been shown to retard aging and inhibit neurodegenerative disorders, ischemia/reperfusion, septic shock, diabetes, cancer, and other complications related to oxidative stress. The purpose of the current study, other than introducing melatonin, was to present the recent findings on clinical effects in diseases related to mitochondrial dysfunction including diabetes, cancer, gastrointestinal diseases, and diseases related to brain function. Medknow Publications & Media Pvt Ltd 2017-01-27 /pmc/articles/PMC5361446/ /pubmed/28400824 http://dx.doi.org/10.4103/1735-1995.199092 Text en Copyright: © 2017 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Sharafati-Chaleshtori, Reza
Shirzad, Hedayatollah
Rafieian-Kopaei, Mahmoud
Soltani, Amin
Melatonin and human mitochondrial diseases
title Melatonin and human mitochondrial diseases
title_full Melatonin and human mitochondrial diseases
title_fullStr Melatonin and human mitochondrial diseases
title_full_unstemmed Melatonin and human mitochondrial diseases
title_short Melatonin and human mitochondrial diseases
title_sort melatonin and human mitochondrial diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361446/
https://www.ncbi.nlm.nih.gov/pubmed/28400824
http://dx.doi.org/10.4103/1735-1995.199092
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