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Melatonin and human mitochondrial diseases
Mitochondrial dysfunction is one of the main causative factors in a wide variety of complications such as neurodegenerative disorders, ischemia/reperfusion, aging process, and septic shock. Decrease in respiratory complex activity, increase in free radical production, increase in mitochondrial synth...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361446/ https://www.ncbi.nlm.nih.gov/pubmed/28400824 http://dx.doi.org/10.4103/1735-1995.199092 |
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author | Sharafati-Chaleshtori, Reza Shirzad, Hedayatollah Rafieian-Kopaei, Mahmoud Soltani, Amin |
author_facet | Sharafati-Chaleshtori, Reza Shirzad, Hedayatollah Rafieian-Kopaei, Mahmoud Soltani, Amin |
author_sort | Sharafati-Chaleshtori, Reza |
collection | PubMed |
description | Mitochondrial dysfunction is one of the main causative factors in a wide variety of complications such as neurodegenerative disorders, ischemia/reperfusion, aging process, and septic shock. Decrease in respiratory complex activity, increase in free radical production, increase in mitochondrial synthase activity, increase in nitric oxide production, and impair in electron transport system and/or mitochondrial permeability are considered as the main factors responsible for mitochondrial dysfunction. Melatonin, the pineal gland hormone, is selectively taken up by mitochondria and acts as a powerful antioxidant, regulating the mitochondrial bioenergetic function. Melatonin increases the permeability of membranes and is the stimulator of antioxidant enzymes including superoxide dismutase, glutathione peroxidase, glutathione reductase, and catalase. It also acts as an inhibitor of lipoxygenase. Melatonin can cause resistance to oxidation damage by fixing the microsomal membranes. Melatonin has been shown to retard aging and inhibit neurodegenerative disorders, ischemia/reperfusion, septic shock, diabetes, cancer, and other complications related to oxidative stress. The purpose of the current study, other than introducing melatonin, was to present the recent findings on clinical effects in diseases related to mitochondrial dysfunction including diabetes, cancer, gastrointestinal diseases, and diseases related to brain function. |
format | Online Article Text |
id | pubmed-5361446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-53614462017-04-11 Melatonin and human mitochondrial diseases Sharafati-Chaleshtori, Reza Shirzad, Hedayatollah Rafieian-Kopaei, Mahmoud Soltani, Amin J Res Med Sci Review Article Mitochondrial dysfunction is one of the main causative factors in a wide variety of complications such as neurodegenerative disorders, ischemia/reperfusion, aging process, and septic shock. Decrease in respiratory complex activity, increase in free radical production, increase in mitochondrial synthase activity, increase in nitric oxide production, and impair in electron transport system and/or mitochondrial permeability are considered as the main factors responsible for mitochondrial dysfunction. Melatonin, the pineal gland hormone, is selectively taken up by mitochondria and acts as a powerful antioxidant, regulating the mitochondrial bioenergetic function. Melatonin increases the permeability of membranes and is the stimulator of antioxidant enzymes including superoxide dismutase, glutathione peroxidase, glutathione reductase, and catalase. It also acts as an inhibitor of lipoxygenase. Melatonin can cause resistance to oxidation damage by fixing the microsomal membranes. Melatonin has been shown to retard aging and inhibit neurodegenerative disorders, ischemia/reperfusion, septic shock, diabetes, cancer, and other complications related to oxidative stress. The purpose of the current study, other than introducing melatonin, was to present the recent findings on clinical effects in diseases related to mitochondrial dysfunction including diabetes, cancer, gastrointestinal diseases, and diseases related to brain function. Medknow Publications & Media Pvt Ltd 2017-01-27 /pmc/articles/PMC5361446/ /pubmed/28400824 http://dx.doi.org/10.4103/1735-1995.199092 Text en Copyright: © 2017 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Sharafati-Chaleshtori, Reza Shirzad, Hedayatollah Rafieian-Kopaei, Mahmoud Soltani, Amin Melatonin and human mitochondrial diseases |
title | Melatonin and human mitochondrial diseases |
title_full | Melatonin and human mitochondrial diseases |
title_fullStr | Melatonin and human mitochondrial diseases |
title_full_unstemmed | Melatonin and human mitochondrial diseases |
title_short | Melatonin and human mitochondrial diseases |
title_sort | melatonin and human mitochondrial diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361446/ https://www.ncbi.nlm.nih.gov/pubmed/28400824 http://dx.doi.org/10.4103/1735-1995.199092 |
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