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The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches
Delivering therapeutics to the central nervous system (CNS) and brain-tumor has been a major challenge. The current standard treatment approaches for the brain-tumor comprise of surgical resection followed by immunotherapy, radiotherapy, and chemotherapy. However, the current treatments are limited...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361495/ https://www.ncbi.nlm.nih.gov/pubmed/28400793 http://dx.doi.org/10.4103/1673-5374.200796 |
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author | Agrahari, Vivek |
author_facet | Agrahari, Vivek |
author_sort | Agrahari, Vivek |
collection | PubMed |
description | Delivering therapeutics to the central nervous system (CNS) and brain-tumor has been a major challenge. The current standard treatment approaches for the brain-tumor comprise of surgical resection followed by immunotherapy, radiotherapy, and chemotherapy. However, the current treatments are limited in providing significant benefits to the patients and despite recent technological advancements; brain-tumor is still challenging to treat. Brain-tumor therapy is limited by the lack of effective and targeted strategies to deliver chemotherapeutic agents across the blood-brain barrier (BBB). The BBB is the main obstacle that must be overcome to allow compounds to reach their targets in the brain. Recent advances have boosted the nanotherapeutic approaches in providing an attractive strategy in improving the drug delivery across the BBB and into the CNS. Compared to conventional formulations, nanoformulations offer significant advantages in CNS drug delivery approaches. Considering the above facts, in this review, the physiological/anatomical features of the brain-tumor and the BBB are briefly discussed. The drug transport mechanisms at the BBB are outlined. The approaches to deliver chemotherapeutic drugs across the CNS into the brain-tumor using nanocarriers are summarized. In addition, the challenges that need to be addressed in nanotherapeutic approaches for their enhanced clinical application in brain-tumor therapy are discussed. |
format | Online Article Text |
id | pubmed-5361495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-53614952017-04-11 The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches Agrahari, Vivek Neural Regen Res Invited Review Delivering therapeutics to the central nervous system (CNS) and brain-tumor has been a major challenge. The current standard treatment approaches for the brain-tumor comprise of surgical resection followed by immunotherapy, radiotherapy, and chemotherapy. However, the current treatments are limited in providing significant benefits to the patients and despite recent technological advancements; brain-tumor is still challenging to treat. Brain-tumor therapy is limited by the lack of effective and targeted strategies to deliver chemotherapeutic agents across the blood-brain barrier (BBB). The BBB is the main obstacle that must be overcome to allow compounds to reach their targets in the brain. Recent advances have boosted the nanotherapeutic approaches in providing an attractive strategy in improving the drug delivery across the BBB and into the CNS. Compared to conventional formulations, nanoformulations offer significant advantages in CNS drug delivery approaches. Considering the above facts, in this review, the physiological/anatomical features of the brain-tumor and the BBB are briefly discussed. The drug transport mechanisms at the BBB are outlined. The approaches to deliver chemotherapeutic drugs across the CNS into the brain-tumor using nanocarriers are summarized. In addition, the challenges that need to be addressed in nanotherapeutic approaches for their enhanced clinical application in brain-tumor therapy are discussed. Medknow Publications & Media Pvt Ltd 2017-02 /pmc/articles/PMC5361495/ /pubmed/28400793 http://dx.doi.org/10.4103/1673-5374.200796 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Invited Review Agrahari, Vivek The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches |
title | The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches |
title_full | The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches |
title_fullStr | The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches |
title_full_unstemmed | The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches |
title_short | The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches |
title_sort | exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361495/ https://www.ncbi.nlm.nih.gov/pubmed/28400793 http://dx.doi.org/10.4103/1673-5374.200796 |
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