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Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8

Tiantai No. 1, a Chinese medicine predominantly composed of powdered Rhizoma Gastrodiae, Radix Ginseng, and Ginkgo leaf at a ratio of 2:1:2 and dissolved in pure water, is neuroprotective in animal models of various cognitive disorders, but its molecular mechanism remains unclear. We administered Ti...

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Autores principales: Li, Ying-hong, Wang, Xu-sheng, Chen, Xiao-lin, Jin, Yu, Chen, Hong-bo, Jia, Xiu-qin, Zhang, Yong-feng, Wu, Zheng-zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361516/
https://www.ncbi.nlm.nih.gov/pubmed/28400814
http://dx.doi.org/10.4103/1673-5374.200813
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author Li, Ying-hong
Wang, Xu-sheng
Chen, Xiao-lin
Jin, Yu
Chen, Hong-bo
Jia, Xiu-qin
Zhang, Yong-feng
Wu, Zheng-zhi
author_facet Li, Ying-hong
Wang, Xu-sheng
Chen, Xiao-lin
Jin, Yu
Chen, Hong-bo
Jia, Xiu-qin
Zhang, Yong-feng
Wu, Zheng-zhi
author_sort Li, Ying-hong
collection PubMed
description Tiantai No. 1, a Chinese medicine predominantly composed of powdered Rhizoma Gastrodiae, Radix Ginseng, and Ginkgo leaf at a ratio of 2:1:2 and dissolved in pure water, is neuroprotective in animal models of various cognitive disorders, but its molecular mechanism remains unclear. We administered Tiantai No. 1 intragastrically to senescence-accelerated mouse prone 8 (SAMP8) mice (a model of Alzheimer's disease) at doses of 50, 100 or 150 mg/kg per day for 8 weeks and evaluated their behavior in the Morris water maze and expression of Alzheimer's disease-related proteins in the brain. Tiantai No. 1 shortened the escape latency in the water maze training trials, and increased swimming time in the target quadrant during the spatial probe test, indicating that Tiantai No. 1 improved learning and memory in SAMP8 mice. Immunohistochemistry revealed that Tiantai No. 1 restored the proliferation potential of Ki67-positive cells in the hippocampus. In addition, mice that had received Tiantai No. 1 had fewer astrocytes, and less accumulation of amyloid-beta and phosphorylated tau. These results suggest that Tiantai No. 1 is neuroprotective in the SAMP8 mouse model of Alzheimer's disease and acts by restoring neuronal number and proliferation potential in the hippocampus, decreasing astrocyte infiltration, and reducing the accumulation of amyloid-beta and phosphorylated tau.
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spelling pubmed-53615162017-04-11 Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8 Li, Ying-hong Wang, Xu-sheng Chen, Xiao-lin Jin, Yu Chen, Hong-bo Jia, Xiu-qin Zhang, Yong-feng Wu, Zheng-zhi Neural Regen Res Research Article Tiantai No. 1, a Chinese medicine predominantly composed of powdered Rhizoma Gastrodiae, Radix Ginseng, and Ginkgo leaf at a ratio of 2:1:2 and dissolved in pure water, is neuroprotective in animal models of various cognitive disorders, but its molecular mechanism remains unclear. We administered Tiantai No. 1 intragastrically to senescence-accelerated mouse prone 8 (SAMP8) mice (a model of Alzheimer's disease) at doses of 50, 100 or 150 mg/kg per day for 8 weeks and evaluated their behavior in the Morris water maze and expression of Alzheimer's disease-related proteins in the brain. Tiantai No. 1 shortened the escape latency in the water maze training trials, and increased swimming time in the target quadrant during the spatial probe test, indicating that Tiantai No. 1 improved learning and memory in SAMP8 mice. Immunohistochemistry revealed that Tiantai No. 1 restored the proliferation potential of Ki67-positive cells in the hippocampus. In addition, mice that had received Tiantai No. 1 had fewer astrocytes, and less accumulation of amyloid-beta and phosphorylated tau. These results suggest that Tiantai No. 1 is neuroprotective in the SAMP8 mouse model of Alzheimer's disease and acts by restoring neuronal number and proliferation potential in the hippocampus, decreasing astrocyte infiltration, and reducing the accumulation of amyloid-beta and phosphorylated tau. Medknow Publications & Media Pvt Ltd 2017-02 /pmc/articles/PMC5361516/ /pubmed/28400814 http://dx.doi.org/10.4103/1673-5374.200813 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Li, Ying-hong
Wang, Xu-sheng
Chen, Xiao-lin
Jin, Yu
Chen, Hong-bo
Jia, Xiu-qin
Zhang, Yong-feng
Wu, Zheng-zhi
Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8
title Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8
title_full Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8
title_fullStr Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8
title_full_unstemmed Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8
title_short Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8
title_sort neuroprotective effect of the chinese medicine tiantai no. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361516/
https://www.ncbi.nlm.nih.gov/pubmed/28400814
http://dx.doi.org/10.4103/1673-5374.200813
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