PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy

Mechanistic target of rapamycin complex 1 (MTORC1) and polo like kinase 1 (PLK1) are major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are currently being investigated in clinical studies. To date, MTORC1′s and PLK1′s functions are mostly studied separatel...

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Detalles Bibliográficos
Autores principales: Ruf, Stefanie, Heberle, Alexander Martin, Langelaar-Makkinje, Miriam, Gelino, Sara, Wilkinson, Deepti, Gerbeth, Carolin, Schwarz, Jennifer Jasmin, Holzwarth, Birgit, Warscheid, Bettina, Meisinger, Chris, van Vugt, Marcel A. T. M., Baumeister, Ralf, Hansen, Malene, Thedieck, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Basic Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361591/
https://www.ncbi.nlm.nih.gov/pubmed/28102733
http://dx.doi.org/10.1080/15548627.2016.1263781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361591/
https://www.ncbi.nlm.nih.gov/pubmed/28102733
http://dx.doi.org/10.1080/15548627.2016.1263781

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