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Characterization of the influence of age on GABA(A) and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG
Gamma-aminobutyric acid (GABA)ergic and glutamatergic neurotransmissions in the prefrontal cortex decreases with age. Further, cognitive function mediated through the dorsolateral prefrontal cortex (DLPFC) also declines with age. Although neuroimaging studies have demonstrated decreased levels of th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361681/ https://www.ncbi.nlm.nih.gov/pubmed/28209926 http://dx.doi.org/10.18632/aging.101178 |
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author | Noda, Yoshihiro Zomorrodi, Reza Cash, Robin F. H. Barr, Mera S. Farzan, Faranak Rajji, Tarek K. Chen, Robert Daskalakis, Zafiris J. Blumberger, Daniel M. |
author_facet | Noda, Yoshihiro Zomorrodi, Reza Cash, Robin F. H. Barr, Mera S. Farzan, Faranak Rajji, Tarek K. Chen, Robert Daskalakis, Zafiris J. Blumberger, Daniel M. |
author_sort | Noda, Yoshihiro |
collection | PubMed |
description | Gamma-aminobutyric acid (GABA)ergic and glutamatergic neurotransmissions in the prefrontal cortex decreases with age. Further, cognitive function mediated through the dorsolateral prefrontal cortex (DLPFC) also declines with age. Although neuroimaging studies have demonstrated decreased levels of these substances, direct neurophysiological data investigating the effect of aging in the DLPFC in human subjects is lacking. The advent of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) has allowed for the assessment of functional neurotransmission in vivo. In the present study, we examined short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) in a group of older adults (> 60 yrs) to evaluate the strength of GABA(A) and glutamate-mediated neurotransmission in the DLPFC, compared to younger adults (18-59 yrs). Older adults showed an increase of amplitude of N100 by the SICI paradigm, while N45 amplitude was increased and N100 amplitude was decreased by ICF. Moreover, these modulations significantly correlated with age. Our findings provide evidence for age-related alterations of excitatory and inhibitory functions in the prefrontal cortex in healthy adults. Future studies may aim to explore these neurophysiological relationships in the DLPFC in pathological forms of aging that affect cortical functioning such as mild cognitive impairment and Alzheimer's disease. |
format | Online Article Text |
id | pubmed-5361681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53616812017-03-29 Characterization of the influence of age on GABA(A) and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG Noda, Yoshihiro Zomorrodi, Reza Cash, Robin F. H. Barr, Mera S. Farzan, Faranak Rajji, Tarek K. Chen, Robert Daskalakis, Zafiris J. Blumberger, Daniel M. Aging (Albany NY) Research Paper Gamma-aminobutyric acid (GABA)ergic and glutamatergic neurotransmissions in the prefrontal cortex decreases with age. Further, cognitive function mediated through the dorsolateral prefrontal cortex (DLPFC) also declines with age. Although neuroimaging studies have demonstrated decreased levels of these substances, direct neurophysiological data investigating the effect of aging in the DLPFC in human subjects is lacking. The advent of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) has allowed for the assessment of functional neurotransmission in vivo. In the present study, we examined short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) in a group of older adults (> 60 yrs) to evaluate the strength of GABA(A) and glutamate-mediated neurotransmission in the DLPFC, compared to younger adults (18-59 yrs). Older adults showed an increase of amplitude of N100 by the SICI paradigm, while N45 amplitude was increased and N100 amplitude was decreased by ICF. Moreover, these modulations significantly correlated with age. Our findings provide evidence for age-related alterations of excitatory and inhibitory functions in the prefrontal cortex in healthy adults. Future studies may aim to explore these neurophysiological relationships in the DLPFC in pathological forms of aging that affect cortical functioning such as mild cognitive impairment and Alzheimer's disease. Impact Journals LLC 2017-02-16 /pmc/articles/PMC5361681/ /pubmed/28209926 http://dx.doi.org/10.18632/aging.101178 Text en Copyright: © 2017 Noda et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Noda, Yoshihiro Zomorrodi, Reza Cash, Robin F. H. Barr, Mera S. Farzan, Faranak Rajji, Tarek K. Chen, Robert Daskalakis, Zafiris J. Blumberger, Daniel M. Characterization of the influence of age on GABA(A) and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG |
title | Characterization of the influence of age on GABA(A) and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG |
title_full | Characterization of the influence of age on GABA(A) and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG |
title_fullStr | Characterization of the influence of age on GABA(A) and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG |
title_full_unstemmed | Characterization of the influence of age on GABA(A) and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG |
title_short | Characterization of the influence of age on GABA(A) and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse TMS-EEG |
title_sort | characterization of the influence of age on gaba(a) and glutamatergic mediated functions in the dorsolateral prefrontal cortex using paired-pulse tms-eeg |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361681/ https://www.ncbi.nlm.nih.gov/pubmed/28209926 http://dx.doi.org/10.18632/aging.101178 |
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