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Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda

BACKGROUND: Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth the odds of symptomatic malaria compared to t...

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Detalles Bibliográficos
Autores principales:	Tukwasibwe, Stephen, Tumwebaze, Patrick, Conrad, Melissa, Arinaitwe, Emmanuel, Kamya, Moses R., Dorsey, Grant, Nsobya, Samuel L., Greenhouse, Bryan, Rosenthal, Philip J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361791/ https://www.ncbi.nlm.nih.gov/pubmed/28327148 http://dx.doi.org/10.1186/s12936-017-1777-0

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