Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

BACKGROUND: Amyloid-β oligomers (oAβ) are thought to mediate neurotoxicity in Alzheimer’s disease (AD), and previous studies in AD transgenic mice suggest that calcium dysregulation may contribute to these pathological effects. Even though AD mouse models remain a valuable resource to investigate am...

Descripción completa

Detalles Bibliográficos
Autores principales: Arbel-Ornath, Michal, Hudry, Eloise, Boivin, Josiah R., Hashimoto, Tadafumi, Takeda, Shuko, Kuchibhotla, Kishore V., Hou, Steven, Lattarulo, Carli R., Belcher, Arianna M., Shakerdge, Naomi, Trujillo, Pariss B., Muzikansky, Alona, Betensky, Rebecca A., Hyman, Bradley T., Bacskai, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361864/
https://www.ncbi.nlm.nih.gov/pubmed/28327181
http://dx.doi.org/10.1186/s13024-017-0169-9

Ejemplares similares

Ejemplares similares