Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition

Compounds targeting phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling are being investigated in multiple clinical settings, but drug resistance may reduce their benefit. Compound rechallenge after drug holidays can overcome such resistance, yet little is known about t...

Descripción completa

Detalles Bibliográficos
Autores principales: Dermit, M, Casado, P, Rajeeve, V, Wilkes, E H, Foxler, D E, Campbell, H, Critchlow, S, Sharp, T V, Gribben, J G, Unwin, R, Cutillas, P R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362070/
https://www.ncbi.nlm.nih.gov/pubmed/27991931
http://dx.doi.org/10.1038/onc.2016.435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362070/
https://www.ncbi.nlm.nih.gov/pubmed/27991931
http://dx.doi.org/10.1038/onc.2016.435

Ejemplares similares