Cargando…
Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis
OBJECTIVES: To evaluate whether urinary iodine concentration (UIC) can predict goiter among school-age children, and to assess the association between UIC and goiter prevalence. METHODS: We searched the MEDLINE, EMBASE, Cochrane Library (Cochrane Database of Systematic Reviews), Web of Science, CNKI...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362073/ https://www.ncbi.nlm.nih.gov/pubmed/28328929 http://dx.doi.org/10.1371/journal.pone.0174095 |
_version_ | 1782516896480886784 |
---|---|
author | Xiu, Linlin Zhong, Gansheng Ma, Xueman |
author_facet | Xiu, Linlin Zhong, Gansheng Ma, Xueman |
author_sort | Xiu, Linlin |
collection | PubMed |
description | OBJECTIVES: To evaluate whether urinary iodine concentration (UIC) can predict goiter among school-age children, and to assess the association between UIC and goiter prevalence. METHODS: We searched the MEDLINE, EMBASE, Cochrane Library (Cochrane Database of Systematic Reviews), Web of Science, CNKI, VIP, and Wan Fang databases for relevant reports in both English and Chinese up to August 25, 2016. The mean differences (MD) and 95% confidence intervals (CI) were calculated for the UIC and goiter prevalence assessments. Pooled odds ratios and 95% CIs were used to compare the prevalences of goiter in the different UIC groups. RESULTS: We identified 11 case-control studies, and found that children with goiter had lower UIC values, compared to children without goiter (MD: –1.82, 95% CI: –3.24, –0.40, p < 0.05). An increased risk of goiter was associated with UIC values of < 20 μg/L or > 200 μg/L. CONCLUSION: The results of our meta-analysis suggest that lower UIC values were associated with an increased risk of goiter, and that iodine deficiency may lead to an increased risk of goiter. Furthermore, we observed U-shaped relationships between UIC and the prevalence of goiter, which suggests that both severe iodine deficiency and excessive iodine intake may lead to increased risks of goiter. |
format | Online Article Text |
id | pubmed-5362073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53620732017-04-06 Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis Xiu, Linlin Zhong, Gansheng Ma, Xueman PLoS One Research Article OBJECTIVES: To evaluate whether urinary iodine concentration (UIC) can predict goiter among school-age children, and to assess the association between UIC and goiter prevalence. METHODS: We searched the MEDLINE, EMBASE, Cochrane Library (Cochrane Database of Systematic Reviews), Web of Science, CNKI, VIP, and Wan Fang databases for relevant reports in both English and Chinese up to August 25, 2016. The mean differences (MD) and 95% confidence intervals (CI) were calculated for the UIC and goiter prevalence assessments. Pooled odds ratios and 95% CIs were used to compare the prevalences of goiter in the different UIC groups. RESULTS: We identified 11 case-control studies, and found that children with goiter had lower UIC values, compared to children without goiter (MD: –1.82, 95% CI: –3.24, –0.40, p < 0.05). An increased risk of goiter was associated with UIC values of < 20 μg/L or > 200 μg/L. CONCLUSION: The results of our meta-analysis suggest that lower UIC values were associated with an increased risk of goiter, and that iodine deficiency may lead to an increased risk of goiter. Furthermore, we observed U-shaped relationships between UIC and the prevalence of goiter, which suggests that both severe iodine deficiency and excessive iodine intake may lead to increased risks of goiter. Public Library of Science 2017-03-22 /pmc/articles/PMC5362073/ /pubmed/28328929 http://dx.doi.org/10.1371/journal.pone.0174095 Text en © 2017 Xiu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Xiu, Linlin Zhong, Gansheng Ma, Xueman Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis |
title | Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis |
title_full | Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis |
title_fullStr | Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis |
title_full_unstemmed | Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis |
title_short | Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis |
title_sort | urinary iodine concentration (uic) could be a promising biomarker for predicting goiter among school-age children: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362073/ https://www.ncbi.nlm.nih.gov/pubmed/28328929 http://dx.doi.org/10.1371/journal.pone.0174095 |
work_keys_str_mv | AT xiulinlin urinaryiodineconcentrationuiccouldbeapromisingbiomarkerforpredictinggoiteramongschoolagechildrenasystematicreviewandmetaanalysis AT zhonggansheng urinaryiodineconcentrationuiccouldbeapromisingbiomarkerforpredictinggoiteramongschoolagechildrenasystematicreviewandmetaanalysis AT maxueman urinaryiodineconcentrationuiccouldbeapromisingbiomarkerforpredictinggoiteramongschoolagechildrenasystematicreviewandmetaanalysis |