Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors

We describe a case of a 25-year-old female with a dopamine secreting PPGL diagnosed retrospectively with biochemical analysis. This finding resulted in change in approach to investigation and management, given their important clinical implications. There are important differences in management of do...

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Detalles Bibliográficos
Autores principales: Bozin, Michael, Lamb, Alastair, Putra, Lydia Johns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362136/
https://www.ncbi.nlm.nih.gov/pubmed/28337414
http://dx.doi.org/10.1016/j.eucr.2017.02.002
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author Bozin, Michael
Lamb, Alastair
Putra, Lydia Johns
author_facet Bozin, Michael
Lamb, Alastair
Putra, Lydia Johns
author_sort Bozin, Michael
collection PubMed
description We describe a case of a 25-year-old female with a dopamine secreting PPGL diagnosed retrospectively with biochemical analysis. This finding resulted in change in approach to investigation and management, given their important clinical implications. There are important differences in management of dopamine secreting PPGL compared to classical noradrenaline and adrenaline-secreting PPGL. This includes the risk of peri-operative cardiovascular collapse peri-operatively with alpha/beta blockade, risk of malignancy/recurrence, and associated genetic abnormalities.
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spelling pubmed-53621362017-03-23 Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors Bozin, Michael Lamb, Alastair Putra, Lydia Johns Urol Case Rep Oncology We describe a case of a 25-year-old female with a dopamine secreting PPGL diagnosed retrospectively with biochemical analysis. This finding resulted in change in approach to investigation and management, given their important clinical implications. There are important differences in management of dopamine secreting PPGL compared to classical noradrenaline and adrenaline-secreting PPGL. This includes the risk of peri-operative cardiovascular collapse peri-operatively with alpha/beta blockade, risk of malignancy/recurrence, and associated genetic abnormalities. Elsevier 2017-03-21 /pmc/articles/PMC5362136/ /pubmed/28337414 http://dx.doi.org/10.1016/j.eucr.2017.02.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Bozin, Michael
Lamb, Alastair
Putra, Lydia Johns
Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors
title Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors
title_full Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors
title_fullStr Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors
title_full_unstemmed Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors
title_short Pheochromocytoma with Negative Metanephrines: A Rarity and the Significance of Dopamine Secreting Tumors
title_sort pheochromocytoma with negative metanephrines: a rarity and the significance of dopamine secreting tumors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362136/
https://www.ncbi.nlm.nih.gov/pubmed/28337414
http://dx.doi.org/10.1016/j.eucr.2017.02.002
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AT putralydiajohns pheochromocytomawithnegativemetanephrinesararityandthesignificanceofdopaminesecretingtumors

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