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The stability of insulin solutions in syringes is improved by ensuring lower molecular weight silicone lubricants are absent
Protein drugs such as insulin are almost universally delivered via glass syringes lubricated with silicone oil. It is not uncommon for prefilled syringes (PFS) to become cloudy, which may affect bioavailability or total drug dose. To examine the role, if any, of the silicone oil lubricant in this pr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362151/ https://www.ncbi.nlm.nih.gov/pubmed/28367509 http://dx.doi.org/10.1016/j.heliyon.2017.e00264 |