A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-(D)-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia

Francisella tularensis, a gram–negative facultative intracellular bacterial pathogen, is the causative agent of tularemia and able to infect many mammalian species, including humans. Because of its ability to cause a lethal infection, low infectious dose, and aerosolizable nature, F. tularensis subs...

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Detalles Bibliográficos
Autores principales: Chance, Taylor, Chua, Jennifer, Toothman, Ronald G., Ladner, Jason T., Nuss, Jonathan E., Raymond, Jo Lynne, Biot, Fabrice V., Demons, Samandra, Miller, Lynda, Halasohoris, Stephanie, Mou, Sherry, Koroleva, Galina, Lovett, Sean, Palacios, Gustavo, Vietri, Nicholas J., Worsham, Patricia L., Cote, Christopher K., Kijek, Todd M., Bozue, Joel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362203/
https://www.ncbi.nlm.nih.gov/pubmed/28328947
http://dx.doi.org/10.1371/journal.pone.0174106

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