DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy

Facioscapulohumeral dystrophy (FSHD) is caused by the mis-expression of DUX4 in skeletal muscle cells. DUX4 is a transcription factor that activates genes normally associated with stem cell biology and its mis-expression in FSHD cells results in apoptosis. To identify genes and pathways necessary fo...

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Detalles Bibliográficos
Autores principales: Shadle, Sean C., Zhong, Jun Wen, Campbell, Amy E., Conerly, Melissa L., Jagannathan, Sujatha, Wong, Chao-Jen, Morello, Timothy D., van der Maarel, Silvère M., Tapscott, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362247/
https://www.ncbi.nlm.nih.gov/pubmed/28273136
http://dx.doi.org/10.1371/journal.pgen.1006658

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