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A Case of Miller Fisher Syndrome and Literature Review
Miller Fisher syndrome (MFS) was first recognized by James Collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. Later, it was described in 1956 by Charles Miller Fisher as a possible variant of Guillain-Barré syndrome (GBS). Here, we write a case of a patient with atypical...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362277/ https://www.ncbi.nlm.nih.gov/pubmed/28367386 http://dx.doi.org/10.7759/cureus.1048 |
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author | Bukhari, Sumera Taboada, Javier |
author_facet | Bukhari, Sumera Taboada, Javier |
author_sort | Bukhari, Sumera |
collection | PubMed |
description | Miller Fisher syndrome (MFS) was first recognized by James Collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. Later, it was described in 1956 by Charles Miller Fisher as a possible variant of Guillain-Barré syndrome (GBS). Here, we write a case of a patient with atypical presentation of this clinical triad as the patient presented with double vision initially due to unilateral ocular involvement that progressed to bilateral ophthalmoplegia. He developed weakness of the lower extremities and areflexia subsequently. A diagnosis of MFS was made due to the clinical presentation and the presence of albuminocytologic dissociation in the cerebrospinal fluid (CSF) along with normal results of brain imaging and blood workup. The patient received intravenous immune globulin (IVIG), and his symptoms improved. The initial diagnosis of MFS is based on the clinical presentation and is confirmed by cerebral spinal fluid analysis and clinical neurophysiology studies. This case which emphasizes the knowledge of a rare syndrome can help narrow down the differentials to act promptly and appropriately manage such patients. |
format | Online Article Text |
id | pubmed-5362277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-53622772017-03-31 A Case of Miller Fisher Syndrome and Literature Review Bukhari, Sumera Taboada, Javier Cureus Internal Medicine Miller Fisher syndrome (MFS) was first recognized by James Collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. Later, it was described in 1956 by Charles Miller Fisher as a possible variant of Guillain-Barré syndrome (GBS). Here, we write a case of a patient with atypical presentation of this clinical triad as the patient presented with double vision initially due to unilateral ocular involvement that progressed to bilateral ophthalmoplegia. He developed weakness of the lower extremities and areflexia subsequently. A diagnosis of MFS was made due to the clinical presentation and the presence of albuminocytologic dissociation in the cerebrospinal fluid (CSF) along with normal results of brain imaging and blood workup. The patient received intravenous immune globulin (IVIG), and his symptoms improved. The initial diagnosis of MFS is based on the clinical presentation and is confirmed by cerebral spinal fluid analysis and clinical neurophysiology studies. This case which emphasizes the knowledge of a rare syndrome can help narrow down the differentials to act promptly and appropriately manage such patients. Cureus 2017-02-22 /pmc/articles/PMC5362277/ /pubmed/28367386 http://dx.doi.org/10.7759/cureus.1048 Text en Copyright © 2017, Bukhari et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Bukhari, Sumera Taboada, Javier A Case of Miller Fisher Syndrome and Literature Review |
title | A Case of Miller Fisher Syndrome and Literature Review |
title_full | A Case of Miller Fisher Syndrome and Literature Review |
title_fullStr | A Case of Miller Fisher Syndrome and Literature Review |
title_full_unstemmed | A Case of Miller Fisher Syndrome and Literature Review |
title_short | A Case of Miller Fisher Syndrome and Literature Review |
title_sort | case of miller fisher syndrome and literature review |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362277/ https://www.ncbi.nlm.nih.gov/pubmed/28367386 http://dx.doi.org/10.7759/cureus.1048 |
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