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A Case of Miller Fisher Syndrome and Literature Review

Miller Fisher syndrome (MFS)  was first recognized by James Collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. Later, it was described in 1956 by Charles Miller Fisher as a possible variant of Guillain-Barré syndrome (GBS). Here, we write a case of a patient with atypical...

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Autores principales: Bukhari, Sumera, Taboada, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362277/
https://www.ncbi.nlm.nih.gov/pubmed/28367386
http://dx.doi.org/10.7759/cureus.1048
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author Bukhari, Sumera
Taboada, Javier
author_facet Bukhari, Sumera
Taboada, Javier
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collection PubMed
description Miller Fisher syndrome (MFS)  was first recognized by James Collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. Later, it was described in 1956 by Charles Miller Fisher as a possible variant of Guillain-Barré syndrome (GBS). Here, we write a case of a patient with atypical presentation of this clinical triad as the patient presented with double vision initially due to unilateral ocular involvement that progressed to bilateral ophthalmoplegia. He developed weakness of the lower extremities and areflexia subsequently. A diagnosis of MFS was made due to the clinical presentation and the presence of albuminocytologic dissociation in the cerebrospinal fluid (CSF) along with normal results of brain imaging and blood workup. The patient received intravenous immune globulin (IVIG), and his symptoms improved. The initial diagnosis of MFS is based on the clinical presentation and is confirmed by cerebral spinal fluid analysis and clinical neurophysiology studies. This case which emphasizes the knowledge of a rare syndrome can help narrow down the differentials to act promptly and appropriately manage such patients.
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spelling pubmed-53622772017-03-31 A Case of Miller Fisher Syndrome and Literature Review Bukhari, Sumera Taboada, Javier Cureus Internal Medicine Miller Fisher syndrome (MFS)  was first recognized by James Collier in 1932 as a clinical triad of ataxia, areflexia, and ophthalmoplegia. Later, it was described in 1956 by Charles Miller Fisher as a possible variant of Guillain-Barré syndrome (GBS). Here, we write a case of a patient with atypical presentation of this clinical triad as the patient presented with double vision initially due to unilateral ocular involvement that progressed to bilateral ophthalmoplegia. He developed weakness of the lower extremities and areflexia subsequently. A diagnosis of MFS was made due to the clinical presentation and the presence of albuminocytologic dissociation in the cerebrospinal fluid (CSF) along with normal results of brain imaging and blood workup. The patient received intravenous immune globulin (IVIG), and his symptoms improved. The initial diagnosis of MFS is based on the clinical presentation and is confirmed by cerebral spinal fluid analysis and clinical neurophysiology studies. This case which emphasizes the knowledge of a rare syndrome can help narrow down the differentials to act promptly and appropriately manage such patients. Cureus 2017-02-22 /pmc/articles/PMC5362277/ /pubmed/28367386 http://dx.doi.org/10.7759/cureus.1048 Text en Copyright © 2017, Bukhari et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Bukhari, Sumera
Taboada, Javier
A Case of Miller Fisher Syndrome and Literature Review
title A Case of Miller Fisher Syndrome and Literature Review
title_full A Case of Miller Fisher Syndrome and Literature Review
title_fullStr A Case of Miller Fisher Syndrome and Literature Review
title_full_unstemmed A Case of Miller Fisher Syndrome and Literature Review
title_short A Case of Miller Fisher Syndrome and Literature Review
title_sort case of miller fisher syndrome and literature review
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362277/
https://www.ncbi.nlm.nih.gov/pubmed/28367386
http://dx.doi.org/10.7759/cureus.1048
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