Ligand-Promoted Protein Folding by Biased Kinetic Partitioning

Protein folding in cells occurs in the presence of high concentrations of endogenous binding partners, and exogenous binding partners have been exploited as pharmacological chaperones. A combined mathematical modeling and experimental approach shows that a ligand improves the folding of a destabiliz...

Descripción completa

Detalles Bibliográficos
Autores principales: Hingorani, Karan S., Metcalf, Matthew C., Deming, Derrick T., Garman, Scott C., Powers, Evan T., Gierasch, Lila M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362304/
https://www.ncbi.nlm.nih.gov/pubmed/28218913
http://dx.doi.org/10.1038/nchembio.2303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362304/
https://www.ncbi.nlm.nih.gov/pubmed/28218913
http://dx.doi.org/10.1038/nchembio.2303

Ejemplares similares