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Ligand-Promoted Protein Folding by Biased Kinetic Partitioning
Protein folding in cells occurs in the presence of high concentrations of endogenous binding partners, and exogenous binding partners have been exploited as pharmacological chaperones. A combined mathematical modeling and experimental approach shows that a ligand improves the folding of a destabiliz...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362304/ https://www.ncbi.nlm.nih.gov/pubmed/28218913 http://dx.doi.org/10.1038/nchembio.2303 |