Distinct patterns of infiltrating CD8+ T cells in HPV+ and CD68 macrophages in HPV- oropharyngeal squamous cell carcinomas are associated with better clinical outcome but PD-L1 expression is not prognostic

Immunotherapies are beginning to revolutionise treatment paradigms in oncology with monoclonal antibodies (mAb) targeting T-cell co-inhibitory (e.g. PD-1/PD-L1) and co-stimulatory pathways (e.g. CTLA-4/CD28) demonstrating clinical utility. Some clinical studies demonstrate that responsiveness to PD-...

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Detalles Bibliográficos
Autores principales: Oguejiofor, Kenneth, Galletta-Williams, Henry, Dovedi, Simon J., Roberts, Darren L., Stern, Peter L., West, Catharine M.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362415/
https://www.ncbi.nlm.nih.gov/pubmed/28122336
http://dx.doi.org/10.18632/oncotarget.14796

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