KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species

KLK6 is a serine protease highly expressed in the nervous system. In synucleinopathies, including Parkinson disease, the levels of KLK6 inversely correlate with α-synuclein in CSF. Recently, we suggested that recombinant KLK6 mediates the degradation of extracellular α-synuclein directly and via a p...

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Detalles Bibliográficos
Autores principales: Pampalakis, Georgios, Sykioti, Vasia-Samantha, Ximerakis, Methodios, Stefanakou-Kalakou, Ioanna, Melki, Ronald, Vekrellis, Kostas, Sotiropoulou, Georgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362421/
https://www.ncbi.nlm.nih.gov/pubmed/27845893
http://dx.doi.org/10.18632/oncotarget.13264

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