The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling

Homeobox genes play a critical role in embryonic development, but they have also been implicated in cancer through mechanisms that are largely unknown. While not expressed during normal T-cell development, homeobox transcription factor genes can be reactivated via recurrent chromosomal rearrangement...

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Detalles Bibliográficos
Autores principales: Tan, Yinfei, Sementino, Eleonora, Xu, Jinfei, Pei, Jianming, Liu, Zemin, Ito, Timothy K, Cai, Kathy Q, Peri, Suraj, Klein-Szanto, Andres J.P., Wiest, David L, Testa, Joseph R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362456/
https://www.ncbi.nlm.nih.gov/pubmed/28122332
http://dx.doi.org/10.18632/oncotarget.14784

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