Acquired resistance to LY2874455 in FGFR2-amplified gastric cancer through an emergence of novel FGFR2-ACSL5 fusion

BACKGROUND: Fibroblast growth factor 2 (FGFR2) amplification, occurring in ~2–9% of gastric cancers (GC), is associated with poor overall survival. RESULTS: RNA sequencing identified a novel FGFR2-ACSL5 fusion in the resistant tumor that was absent from the matched pre-treatment tumor. The FGFR2-amp...

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Detalles Bibliográficos
Autores principales: Kim, Sun Young, Ahn, Taejin, Bang, Heejin, Ham, Jun Soo, Kim, Jusun, Kim, Seung Tae, Jang, Jiryeon, Shim, Moonhee, Kang, So Young, Park, Se Hoon, Min, Byung Hoon, Lee, Hyuk, Kang, Won Ki, Kim, Kyoung-Mee, Park, Woongyang, Lee, Jeeyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362463/
https://www.ncbi.nlm.nih.gov/pubmed/28122360
http://dx.doi.org/10.18632/oncotarget.14788

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