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Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice

BACKGROUND: Aging augments endotoxemic cardiac dysfunction, but the mechanism remains unclear. Anti-aging protein Klotho has been found to modulate tissue inflammatory responses. We tested the hypothesis that a reduced Klotho level in aging heart plays a role in the augmented endotoxemic cardiac dys...

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Detalles Bibliográficos
Autores principales:	Hui, Haipeng, Zhai, Yufeng, Ao, Lihua, Cleveland, Joseph C., Liu, Hongbin, Fullerton, David A., Meng, Xianzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362514/ https://www.ncbi.nlm.nih.gov/pubmed/28152512 http://dx.doi.org/10.18632/oncotarget.14933

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