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Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China
The aim of this study was to investigate the independent and combined effects of fatty acid desaturase 1 (FADS1) gene polymorphism and fish consumption on oral cancer. A hospital-based case-control study was performed including 305 oral cancer patients and 579 cancer-free controls. The genotypes wer...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362531/ https://www.ncbi.nlm.nih.gov/pubmed/28178666 http://dx.doi.org/10.18632/oncotarget.15069 |
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author | Chen, Fa Lin, Tao Yan, Lingjun Liu, Fengqiong Huang, Jiangfeng Liu, Fangping Wu, Junfeng Qiu, Yu Lin, Lisong Cai, Lin He, Baochang |
author_facet | Chen, Fa Lin, Tao Yan, Lingjun Liu, Fengqiong Huang, Jiangfeng Liu, Fangping Wu, Junfeng Qiu, Yu Lin, Lisong Cai, Lin He, Baochang |
author_sort | Chen, Fa |
collection | PubMed |
description | The aim of this study was to investigate the independent and combined effects of fatty acid desaturase 1 (FADS1) gene polymorphism and fish consumption on oral cancer. A hospital-based case-control study was performed including 305 oral cancer patients and 579 cancer-free controls. The genotypes were determined by TaqMan genotyping assay. Non-conditional logistic regression model was used to assess the effects of FADS1 rs174549 polymorphism and fish intake. Subjects carrying A allele of rs174549 significantly reduced the risk of oral cancer (AA VS GG, OR: 0.65, 95% CI: 0.42-0.99; AA VS AG+GG, OR: 0.67, 95% CI: 0.46-0.98). Moreover, the statistically significant reverse associations were especially evident in men, smokers, alcohol drinkers and those age ≤ 60 years. Additionally, fish intake ≥7 times/week showed a 73% reduction in risk for oral cancer compared to those who ate fish less than 2 times/week (OR: 0.27, 95% CI: 0.18-0.42). Furthermore, a significant gene-diet multiplicative interaction was observed between FADS1 rs174549 polymorphism and fish intake for oral cancer (P=0.028). This preliminary study suggests that FADS1 rs174549 polymorphism and fish consumption may be protective factors for oral cancer, with a gene-diet multiplicative interaction. Functional studies with larger samples are required to confirm our findings. |
format | Online Article Text |
id | pubmed-5362531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53625312017-04-24 Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China Chen, Fa Lin, Tao Yan, Lingjun Liu, Fengqiong Huang, Jiangfeng Liu, Fangping Wu, Junfeng Qiu, Yu Lin, Lisong Cai, Lin He, Baochang Oncotarget Research Paper The aim of this study was to investigate the independent and combined effects of fatty acid desaturase 1 (FADS1) gene polymorphism and fish consumption on oral cancer. A hospital-based case-control study was performed including 305 oral cancer patients and 579 cancer-free controls. The genotypes were determined by TaqMan genotyping assay. Non-conditional logistic regression model was used to assess the effects of FADS1 rs174549 polymorphism and fish intake. Subjects carrying A allele of rs174549 significantly reduced the risk of oral cancer (AA VS GG, OR: 0.65, 95% CI: 0.42-0.99; AA VS AG+GG, OR: 0.67, 95% CI: 0.46-0.98). Moreover, the statistically significant reverse associations were especially evident in men, smokers, alcohol drinkers and those age ≤ 60 years. Additionally, fish intake ≥7 times/week showed a 73% reduction in risk for oral cancer compared to those who ate fish less than 2 times/week (OR: 0.27, 95% CI: 0.18-0.42). Furthermore, a significant gene-diet multiplicative interaction was observed between FADS1 rs174549 polymorphism and fish intake for oral cancer (P=0.028). This preliminary study suggests that FADS1 rs174549 polymorphism and fish consumption may be protective factors for oral cancer, with a gene-diet multiplicative interaction. Functional studies with larger samples are required to confirm our findings. Impact Journals LLC 2017-02-03 /pmc/articles/PMC5362531/ /pubmed/28178666 http://dx.doi.org/10.18632/oncotarget.15069 Text en Copyright: © 2017 Chen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Chen, Fa Lin, Tao Yan, Lingjun Liu, Fengqiong Huang, Jiangfeng Liu, Fangping Wu, Junfeng Qiu, Yu Lin, Lisong Cai, Lin He, Baochang Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China |
title | Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China |
title_full | Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China |
title_fullStr | Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China |
title_full_unstemmed | Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China |
title_short | Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China |
title_sort | novel polymorphism in fads1 gene and fish consumption on risk of oral cancer: a case-control study in southeast china |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362531/ https://www.ncbi.nlm.nih.gov/pubmed/28178666 http://dx.doi.org/10.18632/oncotarget.15069 |
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