TLE1 function and therapeutic potential in cancer

Groucho (Gro)/Transducin-like enhancer of split (TLE) family proteins act as co-repressors of many transcription factors, and are involved in key signaling pathways. TLE1 negatively regulates inflammation and has potential roles in various diseases, including cancer. Previous studies suggest TLE1 co...

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Detalles Bibliográficos
Autores principales: Yuan, Da, Yang, Xue, Yuan, Zhenpeng, Zhao, Yanqing, Guo, Junchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362539/
https://www.ncbi.nlm.nih.gov/pubmed/27852056
http://dx.doi.org/10.18632/oncotarget.13278
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author Yuan, Da
Yang, Xue
Yuan, Zhenpeng
Zhao, Yanqing
Guo, Junchao
author_facet Yuan, Da
Yang, Xue
Yuan, Zhenpeng
Zhao, Yanqing
Guo, Junchao
author_sort Yuan, Da
collection PubMed
description Groucho (Gro)/Transducin-like enhancer of split (TLE) family proteins act as co-repressors of many transcription factors, and are involved in key signaling pathways. TLE1 negatively regulates inflammation and has potential roles in various diseases, including cancer. Previous studies suggest TLE1 could be used as a diagnostic marker and is a possible therapeutic target in various malignancies. It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis. In this review, we highlight the functions of TLE1 in cancer and explore targeted approaches for cancer diagnosis and treatment. In particular, we discuss the TLE1 function in pancreatic cancer.
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spelling pubmed-53625392017-04-24 TLE1 function and therapeutic potential in cancer Yuan, Da Yang, Xue Yuan, Zhenpeng Zhao, Yanqing Guo, Junchao Oncotarget Review Groucho (Gro)/Transducin-like enhancer of split (TLE) family proteins act as co-repressors of many transcription factors, and are involved in key signaling pathways. TLE1 negatively regulates inflammation and has potential roles in various diseases, including cancer. Previous studies suggest TLE1 could be used as a diagnostic marker and is a possible therapeutic target in various malignancies. It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis. In this review, we highlight the functions of TLE1 in cancer and explore targeted approaches for cancer diagnosis and treatment. In particular, we discuss the TLE1 function in pancreatic cancer. Impact Journals LLC 2016-11-10 /pmc/articles/PMC5362539/ /pubmed/27852056 http://dx.doi.org/10.18632/oncotarget.13278 Text en Copyright: © 2017 Yuan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Yuan, Da
Yang, Xue
Yuan, Zhenpeng
Zhao, Yanqing
Guo, Junchao
TLE1 function and therapeutic potential in cancer
title TLE1 function and therapeutic potential in cancer
title_full TLE1 function and therapeutic potential in cancer
title_fullStr TLE1 function and therapeutic potential in cancer
title_full_unstemmed TLE1 function and therapeutic potential in cancer
title_short TLE1 function and therapeutic potential in cancer
title_sort tle1 function and therapeutic potential in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362539/
https://www.ncbi.nlm.nih.gov/pubmed/27852056
http://dx.doi.org/10.18632/oncotarget.13278
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AT guojunchao tle1functionandtherapeuticpotentialincancer

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