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Prognostic value of RDW in cancers: a systematic review and meta-analysis

Red blood cell distribution width (RDW), a parameter that used to differentiate the type of anemia for several decades, recent studies suggest it was a prognostic factor in various types of cancer patients. However, the prognostic value of RDW in cancer patients remains controversial. Here, we perfo...

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Autores principales: Hu, Linhui, Li, Manman, Ding, Yangyang, Pu, Lianfang, Liu, Jun, Xie, Jingxin, Cabanero, Michael, Li, Jingrong, Xiang, Ru, Xiong, Shudao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362543/
https://www.ncbi.nlm.nih.gov/pubmed/27926498
http://dx.doi.org/10.18632/oncotarget.13784
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author Hu, Linhui
Li, Manman
Ding, Yangyang
Pu, Lianfang
Liu, Jun
Xie, Jingxin
Cabanero, Michael
Li, Jingrong
Xiang, Ru
Xiong, Shudao
author_facet Hu, Linhui
Li, Manman
Ding, Yangyang
Pu, Lianfang
Liu, Jun
Xie, Jingxin
Cabanero, Michael
Li, Jingrong
Xiang, Ru
Xiong, Shudao
author_sort Hu, Linhui
collection PubMed
description Red blood cell distribution width (RDW), a parameter that used to differentiate the type of anemia for several decades, recent studies suggest it was a prognostic factor in various types of cancer patients. However, the prognostic value of RDW in cancer patients remains controversial. Here, we performed a meta-analysis and systematic review to evaluate the prognostic value of RDW in cancer patients. Relevant studies were picked out from the databases of Web of Science, Embase, Pubmed and Cochrane Library. A total of 16 papers with 4267 patients were included in this meta-analysis, and the combined results indicated that elevated RDW was associated with poor over survival (OS) (HR = 1.47, 95%CI:1.29-1.66), poor cancer-specific survival (CSS) (HR = 1.46, 95%CI:1.08-1.85), poor disease-free survival (DFS) (HR = 1.91, 95%CI:1.27-2.56), poor event-free survival (EFS) (HR = 2.98, 95%CI:0.57-5.39) and poor progress-free survival (PFS) (HR = 3.21, 95%CI:0.33-6.75) after treatment. Furthermore, the similar results were observed in subgroup analysis stratified by cancer type, cutoff value of RDW, sample size and ethnicity. In conclusion, this meta-analysis demonstrated that RDW may be a potential prognostic marker in patients with cancer, and high RDW may also be associated with poor outcomes.
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spelling pubmed-53625432017-04-24 Prognostic value of RDW in cancers: a systematic review and meta-analysis Hu, Linhui Li, Manman Ding, Yangyang Pu, Lianfang Liu, Jun Xie, Jingxin Cabanero, Michael Li, Jingrong Xiang, Ru Xiong, Shudao Oncotarget Review Red blood cell distribution width (RDW), a parameter that used to differentiate the type of anemia for several decades, recent studies suggest it was a prognostic factor in various types of cancer patients. However, the prognostic value of RDW in cancer patients remains controversial. Here, we performed a meta-analysis and systematic review to evaluate the prognostic value of RDW in cancer patients. Relevant studies were picked out from the databases of Web of Science, Embase, Pubmed and Cochrane Library. A total of 16 papers with 4267 patients were included in this meta-analysis, and the combined results indicated that elevated RDW was associated with poor over survival (OS) (HR = 1.47, 95%CI:1.29-1.66), poor cancer-specific survival (CSS) (HR = 1.46, 95%CI:1.08-1.85), poor disease-free survival (DFS) (HR = 1.91, 95%CI:1.27-2.56), poor event-free survival (EFS) (HR = 2.98, 95%CI:0.57-5.39) and poor progress-free survival (PFS) (HR = 3.21, 95%CI:0.33-6.75) after treatment. Furthermore, the similar results were observed in subgroup analysis stratified by cancer type, cutoff value of RDW, sample size and ethnicity. In conclusion, this meta-analysis demonstrated that RDW may be a potential prognostic marker in patients with cancer, and high RDW may also be associated with poor outcomes. Impact Journals LLC 2016-12-02 /pmc/articles/PMC5362543/ /pubmed/27926498 http://dx.doi.org/10.18632/oncotarget.13784 Text en Copyright: © 2017 Hu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Hu, Linhui
Li, Manman
Ding, Yangyang
Pu, Lianfang
Liu, Jun
Xie, Jingxin
Cabanero, Michael
Li, Jingrong
Xiang, Ru
Xiong, Shudao
Prognostic value of RDW in cancers: a systematic review and meta-analysis
title Prognostic value of RDW in cancers: a systematic review and meta-analysis
title_full Prognostic value of RDW in cancers: a systematic review and meta-analysis
title_fullStr Prognostic value of RDW in cancers: a systematic review and meta-analysis
title_full_unstemmed Prognostic value of RDW in cancers: a systematic review and meta-analysis
title_short Prognostic value of RDW in cancers: a systematic review and meta-analysis
title_sort prognostic value of rdw in cancers: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362543/
https://www.ncbi.nlm.nih.gov/pubmed/27926498
http://dx.doi.org/10.18632/oncotarget.13784
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