Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications

Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic st...

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Autores principales: Sarvaria, Anushruti, Jawdat, Dunia, Madrigal, J. Alejandro, Saudemont, Aurore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362597/
https://www.ncbi.nlm.nih.gov/pubmed/28386260
http://dx.doi.org/10.3389/fimmu.2017.00329
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author Sarvaria, Anushruti
Jawdat, Dunia
Madrigal, J. Alejandro
Saudemont, Aurore
author_facet Sarvaria, Anushruti
Jawdat, Dunia
Madrigal, J. Alejandro
Saudemont, Aurore
author_sort Sarvaria, Anushruti
collection PubMed
description Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transplantation but as we gain a better understanding of the characteristics of each immune cell that UCB contains, we will also be able to develop new cell therapies for cancer. In this review, we present what is currently known of the phenotype and functions of UCB NK cells and how these cells could be used in the future for cancer immunotherapy.
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spelling pubmed-53625972017-04-06 Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications Sarvaria, Anushruti Jawdat, Dunia Madrigal, J. Alejandro Saudemont, Aurore Front Immunol Immunology Natural killer (NK) cells are lymphocytes of the innate immune system able to kill different targets such as cancer cells and virally infected cells without prior activation making then attractive candidates for cancer immunotherapy. Umbilical cord blood (UCB) has become a source of hematopoietic stem cells for transplantation but as we gain a better understanding of the characteristics of each immune cell that UCB contains, we will also be able to develop new cell therapies for cancer. In this review, we present what is currently known of the phenotype and functions of UCB NK cells and how these cells could be used in the future for cancer immunotherapy. Frontiers Media S.A. 2017-03-23 /pmc/articles/PMC5362597/ /pubmed/28386260 http://dx.doi.org/10.3389/fimmu.2017.00329 Text en Copyright © 2017 Sarvaria, Jawdat, Madrigal and Saudemont. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Sarvaria, Anushruti
Jawdat, Dunia
Madrigal, J. Alejandro
Saudemont, Aurore
Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications
title Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications
title_full Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications
title_fullStr Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications
title_full_unstemmed Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications
title_short Umbilical Cord Blood Natural Killer Cells, Their Characteristics, and Potential Clinical Applications
title_sort umbilical cord blood natural killer cells, their characteristics, and potential clinical applications
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362597/
https://www.ncbi.nlm.nih.gov/pubmed/28386260
http://dx.doi.org/10.3389/fimmu.2017.00329
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