Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm

Abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta common in adults older than 65 years of age. AAA is usually imaged using ultrasound or computed tomography. Molecular imaging technologies employing nanoparticles (NPs) have been proposed as novel ways to quantify pathological pr...

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Autores principales: Emeto, Theophilus I., Alele, Faith O., Smith, Amy M., Smith, Felicity M., Dougan, Tammy, Golledge, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362602/
https://www.ncbi.nlm.nih.gov/pubmed/28386544
http://dx.doi.org/10.3389/fcvm.2017.00016
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author Emeto, Theophilus I.
Alele, Faith O.
Smith, Amy M.
Smith, Felicity M.
Dougan, Tammy
Golledge, Jonathan
author_facet Emeto, Theophilus I.
Alele, Faith O.
Smith, Amy M.
Smith, Felicity M.
Dougan, Tammy
Golledge, Jonathan
author_sort Emeto, Theophilus I.
collection PubMed
description Abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta common in adults older than 65 years of age. AAA is usually imaged using ultrasound or computed tomography. Molecular imaging technologies employing nanoparticles (NPs) have been proposed as novel ways to quantify pathological processes, such as inflammation, within AAAs as a means to identify the risk of rapid progression or rupture. This article reviews the current evidence supporting the role of NP-based imaging in the management of AAA. Currently, ultrasmall superparamagnetic NPs enhanced magnetic resonance imaging appears to hold the greatest potential for imaging macrophage-mediated inflammation in human AAA.
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spelling pubmed-53626022017-04-06 Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm Emeto, Theophilus I. Alele, Faith O. Smith, Amy M. Smith, Felicity M. Dougan, Tammy Golledge, Jonathan Front Cardiovasc Med Cardiovascular Medicine Abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta common in adults older than 65 years of age. AAA is usually imaged using ultrasound or computed tomography. Molecular imaging technologies employing nanoparticles (NPs) have been proposed as novel ways to quantify pathological processes, such as inflammation, within AAAs as a means to identify the risk of rapid progression or rupture. This article reviews the current evidence supporting the role of NP-based imaging in the management of AAA. Currently, ultrasmall superparamagnetic NPs enhanced magnetic resonance imaging appears to hold the greatest potential for imaging macrophage-mediated inflammation in human AAA. Frontiers Media S.A. 2017-03-23 /pmc/articles/PMC5362602/ /pubmed/28386544 http://dx.doi.org/10.3389/fcvm.2017.00016 Text en Copyright © 2017 Emeto, Alele, Smith, Smith, Dougan and Golledge. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Emeto, Theophilus I.
Alele, Faith O.
Smith, Amy M.
Smith, Felicity M.
Dougan, Tammy
Golledge, Jonathan
Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm
title Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm
title_full Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm
title_fullStr Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm
title_full_unstemmed Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm
title_short Use of Nanoparticles As Contrast Agents for the Functional and Molecular Imaging of Abdominal Aortic Aneurysm
title_sort use of nanoparticles as contrast agents for the functional and molecular imaging of abdominal aortic aneurysm
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362602/
https://www.ncbi.nlm.nih.gov/pubmed/28386544
http://dx.doi.org/10.3389/fcvm.2017.00016
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