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Role of Anti-Osteopontin Antibodies in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Osteopontin (OPN) is highly expressed in demyelinating lesions in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). OPN is cleaved by thrombin into N- (OPN-N) and C-terminal (OPN-C) fragments with different ligands and functions. In EAE, administering recombinant OPN induc...

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Detalles Bibliográficos
Autores principales:	Clemente, Nausicaa, Comi, Cristoforo, Raineri, Davide, Cappellano, Giuseppe, Vecchio, Domizia, Orilieri, Elisabetta, Gigliotti, Casimiro L., Boggio, Elena, Dianzani, Chiara, Sorosina, Melissa, Martinelli-Boneschi, Filippo, Caldano, Marzia, Bertolotto, Antonio, Ambrogio, Luca, Sblattero, Daniele, Cena, Tiziana, Leone, Maurizio, Dianzani, Umberto, Chiocchetti, Annalisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362623/ https://www.ncbi.nlm.nih.gov/pubmed/28386258 http://dx.doi.org/10.3389/fimmu.2017.00321

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