Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)

Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we...

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Detalles Bibliográficos
Autores principales: Ritter, McKenzie L., Guo, Wei, Samuels, Jack F., Wang, Ying, Nestadt, Paul S., Krasnow, Janice, Greenberg, Benjamin D., Fyer, Abby J., McCracken, James T., Geller, Daniel A., Murphy, Dennis L., Knowles, James A., Grados, Marco A., Riddle, Mark A., Rasmussen, Steven A., McLaughlin, Nicole C., Nurmi, Erika L., Askland, Kathleen D., Cullen, Bernadette, Piacentini, John, Pauls, David L., Bienvenu, Joseph, Stewart, Evelyn, Goes, Fernando S., Maher, Brion, Pulver, Ann E., Mattheisen, Manuel, Qian, Ji, Nestadt, Gerald, Shugart, Yin Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362635/
https://www.ncbi.nlm.nih.gov/pubmed/28386217
http://dx.doi.org/10.3389/fnmol.2017.00083
Descripción
Sumario:Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.

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