Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)

Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Ritter, McKenzie L., Guo, Wei, Samuels, Jack F., Wang, Ying, Nestadt, Paul S., Krasnow, Janice, Greenberg, Benjamin D., Fyer, Abby J., McCracken, James T., Geller, Daniel A., Murphy, Dennis L., Knowles, James A., Grados, Marco A., Riddle, Mark A., Rasmussen, Steven A., McLaughlin, Nicole C., Nurmi, Erika L., Askland, Kathleen D., Cullen, Bernadette, Piacentini, John, Pauls, David L., Bienvenu, Joseph, Stewart, Evelyn, Goes, Fernando S., Maher, Brion, Pulver, Ann E., Mattheisen, Manuel, Qian, Ji, Nestadt, Gerald, Shugart, Yin Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362635/
https://www.ncbi.nlm.nih.gov/pubmed/28386217
http://dx.doi.org/10.3389/fnmol.2017.00083
_version_ 1782516989750673408
author Ritter, McKenzie L.
Guo, Wei
Samuels, Jack F.
Wang, Ying
Nestadt, Paul S.
Krasnow, Janice
Greenberg, Benjamin D.
Fyer, Abby J.
McCracken, James T.
Geller, Daniel A.
Murphy, Dennis L.
Knowles, James A.
Grados, Marco A.
Riddle, Mark A.
Rasmussen, Steven A.
McLaughlin, Nicole C.
Nurmi, Erika L.
Askland, Kathleen D.
Cullen, Bernadette
Piacentini, John
Pauls, David L.
Bienvenu, Joseph
Stewart, Evelyn
Goes, Fernando S.
Maher, Brion
Pulver, Ann E.
Mattheisen, Manuel
Qian, Ji
Nestadt, Gerald
Shugart, Yin Yao
author_facet Ritter, McKenzie L.
Guo, Wei
Samuels, Jack F.
Wang, Ying
Nestadt, Paul S.
Krasnow, Janice
Greenberg, Benjamin D.
Fyer, Abby J.
McCracken, James T.
Geller, Daniel A.
Murphy, Dennis L.
Knowles, James A.
Grados, Marco A.
Riddle, Mark A.
Rasmussen, Steven A.
McLaughlin, Nicole C.
Nurmi, Erika L.
Askland, Kathleen D.
Cullen, Bernadette
Piacentini, John
Pauls, David L.
Bienvenu, Joseph
Stewart, Evelyn
Goes, Fernando S.
Maher, Brion
Pulver, Ann E.
Mattheisen, Manuel
Qian, Ji
Nestadt, Gerald
Shugart, Yin Yao
author_sort Ritter, McKenzie L.
collection PubMed
description Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.
format Online
Article
Text
id pubmed-5362635
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-53626352017-04-06 Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD) Ritter, McKenzie L. Guo, Wei Samuels, Jack F. Wang, Ying Nestadt, Paul S. Krasnow, Janice Greenberg, Benjamin D. Fyer, Abby J. McCracken, James T. Geller, Daniel A. Murphy, Dennis L. Knowles, James A. Grados, Marco A. Riddle, Mark A. Rasmussen, Steven A. McLaughlin, Nicole C. Nurmi, Erika L. Askland, Kathleen D. Cullen, Bernadette Piacentini, John Pauls, David L. Bienvenu, Joseph Stewart, Evelyn Goes, Fernando S. Maher, Brion Pulver, Ann E. Mattheisen, Manuel Qian, Ji Nestadt, Gerald Shugart, Yin Yao Front Mol Neurosci Neuroscience Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD. Frontiers Media S.A. 2017-03-23 /pmc/articles/PMC5362635/ /pubmed/28386217 http://dx.doi.org/10.3389/fnmol.2017.00083 Text en Copyright © 2017 Ritter, Guo, Samuels, Wang, Nestadt, Krasnow, Greenberg, Fyer, McCracken, Geller, Murphy, Knowles, Grados, Riddle, Rasmussen, McLaughlin, Nurmi, Askland, Cullen, Piacentini, Pauls, Bienvenu, Stewart, Goes, Maher, Pulver, Mattheisen, Qian, Nestadt and Shugart. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ritter, McKenzie L.
Guo, Wei
Samuels, Jack F.
Wang, Ying
Nestadt, Paul S.
Krasnow, Janice
Greenberg, Benjamin D.
Fyer, Abby J.
McCracken, James T.
Geller, Daniel A.
Murphy, Dennis L.
Knowles, James A.
Grados, Marco A.
Riddle, Mark A.
Rasmussen, Steven A.
McLaughlin, Nicole C.
Nurmi, Erika L.
Askland, Kathleen D.
Cullen, Bernadette
Piacentini, John
Pauls, David L.
Bienvenu, Joseph
Stewart, Evelyn
Goes, Fernando S.
Maher, Brion
Pulver, Ann E.
Mattheisen, Manuel
Qian, Ji
Nestadt, Gerald
Shugart, Yin Yao
Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
title Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
title_full Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
title_fullStr Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
title_full_unstemmed Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
title_short Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)
title_sort genome wide association study (gwas) between attention deficit hyperactivity disorder (adhd) and obsessive compulsive disorder (ocd)
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362635/
https://www.ncbi.nlm.nih.gov/pubmed/28386217
http://dx.doi.org/10.3389/fnmol.2017.00083
work_keys_str_mv AT rittermckenziel genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT guowei genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT samuelsjackf genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT wangying genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT nestadtpauls genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT krasnowjanice genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT greenbergbenjamind genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT fyerabbyj genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT mccrackenjamest genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT gellerdaniela genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT murphydennisl genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT knowlesjamesa genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT gradosmarcoa genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT riddlemarka genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT rasmussenstevena genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT mclaughlinnicolec genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT nurmierikal genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT asklandkathleend genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT cullenbernadette genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT piacentinijohn genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT paulsdavidl genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT bienvenujoseph genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT stewartevelyn genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT goesfernandos genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT maherbrion genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT pulveranne genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT mattheisenmanuel genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT qianji genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT nestadtgerald genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd
AT shugartyinyao genomewideassociationstudygwasbetweenattentiondeficithyperactivitydisorderadhdandobsessivecompulsivedisorderocd

Ejemplares similares