Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice

RAS signaling is central to many cellular processes and SOS proteins promote RAS activation. To investigate the role of SOS proteins in T cell biology, we crossed Sos1(f/f) Sos2(−/−) mice to CD4-Cre transgenic mice. We previously reported an effect of these mutations on T cell signaling and T cell m...

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Detalles Bibliográficos
Autores principales: Guittard, Geoffrey, Gallardo, Devorah L., Li, Wenmei, Melis, Nicolas, Lui, Julian C., Kortum, Robert L., Shakarishvili, Nicholas G., Huh, Sunmee, Baron, Jeffrey, Weigert, Roberto, Kramer, Joshua A., Samelson, Lawrence E., Sommers, Connie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362643/
https://www.ncbi.nlm.nih.gov/pubmed/28386265
http://dx.doi.org/10.3389/fimmu.2017.00343

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