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Soft 3D-Printed Phantom of the Human Kidney with Collecting System
Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362658/ https://www.ncbi.nlm.nih.gov/pubmed/27830490 http://dx.doi.org/10.1007/s10439-016-1757-5 |
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author | Adams, Fabian Qiu, Tian Mark, Andrew Fritz, Benjamin Kramer, Lena Schlager, Daniel Wetterauer, Ulrich Miernik, Arkadiusz Fischer, Peer |
author_facet | Adams, Fabian Qiu, Tian Mark, Andrew Fritz, Benjamin Kramer, Lena Schlager, Daniel Wetterauer, Ulrich Miernik, Arkadiusz Fischer, Peer |
author_sort | Adams, Fabian |
collection | PubMed |
description | Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical properties of human organs. In this paper, we report a novel fabrication process to make a human kidney phantom with realistic anatomical structures and physical properties. The detailed anatomical structure was directly acquired from high resolution CT data sets of human cadaveric kidneys. The soft phantoms were constructed using a novel technique that combines 3D wax printing and polymer molding. Anatomical details and material properties of the phantoms were validated in detail by CT scan, ultrasound, and endoscopy. CT reconstruction, ultrasound examination, and endoscopy showed that the designed phantom mimics a real kidney’s detailed anatomy and correctly corresponds to the targeted human cadaver’s upper urinary tract. Soft materials with a tensile modulus of 0.8–1.5 MPa as well as biocompatible hydrogels were used to mimic human kidney tissues. We developed a method of constructing 3D organ models from medical imaging data using a 3D wax printing and molding process. This method is cost-effective means for obtaining a reproducible and robust model suitable for surgical simulation and training purposes. |
format | Online Article Text |
id | pubmed-5362658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-53626582017-04-20 Soft 3D-Printed Phantom of the Human Kidney with Collecting System Adams, Fabian Qiu, Tian Mark, Andrew Fritz, Benjamin Kramer, Lena Schlager, Daniel Wetterauer, Ulrich Miernik, Arkadiusz Fischer, Peer Ann Biomed Eng Article Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical properties of human organs. In this paper, we report a novel fabrication process to make a human kidney phantom with realistic anatomical structures and physical properties. The detailed anatomical structure was directly acquired from high resolution CT data sets of human cadaveric kidneys. The soft phantoms were constructed using a novel technique that combines 3D wax printing and polymer molding. Anatomical details and material properties of the phantoms were validated in detail by CT scan, ultrasound, and endoscopy. CT reconstruction, ultrasound examination, and endoscopy showed that the designed phantom mimics a real kidney’s detailed anatomy and correctly corresponds to the targeted human cadaver’s upper urinary tract. Soft materials with a tensile modulus of 0.8–1.5 MPa as well as biocompatible hydrogels were used to mimic human kidney tissues. We developed a method of constructing 3D organ models from medical imaging data using a 3D wax printing and molding process. This method is cost-effective means for obtaining a reproducible and robust model suitable for surgical simulation and training purposes. Springer US 2016-11-09 2017 /pmc/articles/PMC5362658/ /pubmed/27830490 http://dx.doi.org/10.1007/s10439-016-1757-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Adams, Fabian Qiu, Tian Mark, Andrew Fritz, Benjamin Kramer, Lena Schlager, Daniel Wetterauer, Ulrich Miernik, Arkadiusz Fischer, Peer Soft 3D-Printed Phantom of the Human Kidney with Collecting System |
title | Soft 3D-Printed Phantom of the Human Kidney with Collecting System |
title_full | Soft 3D-Printed Phantom of the Human Kidney with Collecting System |
title_fullStr | Soft 3D-Printed Phantom of the Human Kidney with Collecting System |
title_full_unstemmed | Soft 3D-Printed Phantom of the Human Kidney with Collecting System |
title_short | Soft 3D-Printed Phantom of the Human Kidney with Collecting System |
title_sort | soft 3d-printed phantom of the human kidney with collecting system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362658/ https://www.ncbi.nlm.nih.gov/pubmed/27830490 http://dx.doi.org/10.1007/s10439-016-1757-5 |
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