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Soft 3D-Printed Phantom of the Human Kidney with Collecting System

Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology...

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Autores principales: Adams, Fabian, Qiu, Tian, Mark, Andrew, Fritz, Benjamin, Kramer, Lena, Schlager, Daniel, Wetterauer, Ulrich, Miernik, Arkadiusz, Fischer, Peer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362658/
https://www.ncbi.nlm.nih.gov/pubmed/27830490
http://dx.doi.org/10.1007/s10439-016-1757-5
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author Adams, Fabian
Qiu, Tian
Mark, Andrew
Fritz, Benjamin
Kramer, Lena
Schlager, Daniel
Wetterauer, Ulrich
Miernik, Arkadiusz
Fischer, Peer
author_facet Adams, Fabian
Qiu, Tian
Mark, Andrew
Fritz, Benjamin
Kramer, Lena
Schlager, Daniel
Wetterauer, Ulrich
Miernik, Arkadiusz
Fischer, Peer
author_sort Adams, Fabian
collection PubMed
description Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical properties of human organs. In this paper, we report a novel fabrication process to make a human kidney phantom with realistic anatomical structures and physical properties. The detailed anatomical structure was directly acquired from high resolution CT data sets of human cadaveric kidneys. The soft phantoms were constructed using a novel technique that combines 3D wax printing and polymer molding. Anatomical details and material properties of the phantoms were validated in detail by CT scan, ultrasound, and endoscopy. CT reconstruction, ultrasound examination, and endoscopy showed that the designed phantom mimics a real kidney’s detailed anatomy and correctly corresponds to the targeted human cadaver’s upper urinary tract. Soft materials with a tensile modulus of 0.8–1.5 MPa as well as biocompatible hydrogels were used to mimic human kidney tissues. We developed a method of constructing 3D organ models from medical imaging data using a 3D wax printing and molding process. This method is cost-effective means for obtaining a reproducible and robust model suitable for surgical simulation and training purposes.
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spelling pubmed-53626582017-04-20 Soft 3D-Printed Phantom of the Human Kidney with Collecting System Adams, Fabian Qiu, Tian Mark, Andrew Fritz, Benjamin Kramer, Lena Schlager, Daniel Wetterauer, Ulrich Miernik, Arkadiusz Fischer, Peer Ann Biomed Eng Article Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical properties of human organs. In this paper, we report a novel fabrication process to make a human kidney phantom with realistic anatomical structures and physical properties. The detailed anatomical structure was directly acquired from high resolution CT data sets of human cadaveric kidneys. The soft phantoms were constructed using a novel technique that combines 3D wax printing and polymer molding. Anatomical details and material properties of the phantoms were validated in detail by CT scan, ultrasound, and endoscopy. CT reconstruction, ultrasound examination, and endoscopy showed that the designed phantom mimics a real kidney’s detailed anatomy and correctly corresponds to the targeted human cadaver’s upper urinary tract. Soft materials with a tensile modulus of 0.8–1.5 MPa as well as biocompatible hydrogels were used to mimic human kidney tissues. We developed a method of constructing 3D organ models from medical imaging data using a 3D wax printing and molding process. This method is cost-effective means for obtaining a reproducible and robust model suitable for surgical simulation and training purposes. Springer US 2016-11-09 2017 /pmc/articles/PMC5362658/ /pubmed/27830490 http://dx.doi.org/10.1007/s10439-016-1757-5 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Adams, Fabian
Qiu, Tian
Mark, Andrew
Fritz, Benjamin
Kramer, Lena
Schlager, Daniel
Wetterauer, Ulrich
Miernik, Arkadiusz
Fischer, Peer
Soft 3D-Printed Phantom of the Human Kidney with Collecting System
title Soft 3D-Printed Phantom of the Human Kidney with Collecting System
title_full Soft 3D-Printed Phantom of the Human Kidney with Collecting System
title_fullStr Soft 3D-Printed Phantom of the Human Kidney with Collecting System
title_full_unstemmed Soft 3D-Printed Phantom of the Human Kidney with Collecting System
title_short Soft 3D-Printed Phantom of the Human Kidney with Collecting System
title_sort soft 3d-printed phantom of the human kidney with collecting system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362658/
https://www.ncbi.nlm.nih.gov/pubmed/27830490
http://dx.doi.org/10.1007/s10439-016-1757-5
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