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Low lifetime stress exposure is associated with reduced stimulus–response memory

Exposure to stress throughout life can cumulatively influence later health, even among young adults. The negative effects of high cumulative stress exposure are well-known, and a shift from episodic to stimulus–response memory has been proposed to underlie forms of psychopathology that are related t...

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Autores principales: Goldfarb, Elizabeth V., Shields, Grant S., Daw, Nathaniel D., Slavich, George M., Phelps, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362698/
https://www.ncbi.nlm.nih.gov/pubmed/28298555
http://dx.doi.org/10.1101/lm.045179.117
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author Goldfarb, Elizabeth V.
Shields, Grant S.
Daw, Nathaniel D.
Slavich, George M.
Phelps, Elizabeth A.
author_facet Goldfarb, Elizabeth V.
Shields, Grant S.
Daw, Nathaniel D.
Slavich, George M.
Phelps, Elizabeth A.
author_sort Goldfarb, Elizabeth V.
collection PubMed
description Exposure to stress throughout life can cumulatively influence later health, even among young adults. The negative effects of high cumulative stress exposure are well-known, and a shift from episodic to stimulus–response memory has been proposed to underlie forms of psychopathology that are related to high lifetime stress. At the other extreme, effects of very low stress exposure are mixed, with some studies reporting that low stress leads to better outcomes, while others demonstrate that low stress is associated with diminished resilience and negative outcomes. However, the influence of very low lifetime stress exposure on episodic and stimulus–response memory is unknown. Here we use a lifetime stress assessment system (STRAIN) to assess cumulative lifetime stress exposure and measure memory performance in young adults reporting very low and moderate levels of lifetime stress exposure. Relative to moderate levels of stress, very low levels of lifetime stress were associated with reduced use and retention (24 h later) of stimulus–response (SR) associations, and a higher likelihood of using context memory. Further, computational modeling revealed that participants with low levels of stress exhibited worse expression of memory for SR associations than those with moderate stress. These results demonstrate that very low levels of stress exposure can have negative effects on cognition.
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spelling pubmed-53626982018-04-01 Low lifetime stress exposure is associated with reduced stimulus–response memory Goldfarb, Elizabeth V. Shields, Grant S. Daw, Nathaniel D. Slavich, George M. Phelps, Elizabeth A. Learn Mem Research Exposure to stress throughout life can cumulatively influence later health, even among young adults. The negative effects of high cumulative stress exposure are well-known, and a shift from episodic to stimulus–response memory has been proposed to underlie forms of psychopathology that are related to high lifetime stress. At the other extreme, effects of very low stress exposure are mixed, with some studies reporting that low stress leads to better outcomes, while others demonstrate that low stress is associated with diminished resilience and negative outcomes. However, the influence of very low lifetime stress exposure on episodic and stimulus–response memory is unknown. Here we use a lifetime stress assessment system (STRAIN) to assess cumulative lifetime stress exposure and measure memory performance in young adults reporting very low and moderate levels of lifetime stress exposure. Relative to moderate levels of stress, very low levels of lifetime stress were associated with reduced use and retention (24 h later) of stimulus–response (SR) associations, and a higher likelihood of using context memory. Further, computational modeling revealed that participants with low levels of stress exhibited worse expression of memory for SR associations than those with moderate stress. These results demonstrate that very low levels of stress exposure can have negative effects on cognition. Cold Spring Harbor Laboratory Press 2017-04 /pmc/articles/PMC5362698/ /pubmed/28298555 http://dx.doi.org/10.1101/lm.045179.117 Text en © 2017 Goldfarb et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research
Goldfarb, Elizabeth V.
Shields, Grant S.
Daw, Nathaniel D.
Slavich, George M.
Phelps, Elizabeth A.
Low lifetime stress exposure is associated with reduced stimulus–response memory
title Low lifetime stress exposure is associated with reduced stimulus–response memory
title_full Low lifetime stress exposure is associated with reduced stimulus–response memory
title_fullStr Low lifetime stress exposure is associated with reduced stimulus–response memory
title_full_unstemmed Low lifetime stress exposure is associated with reduced stimulus–response memory
title_short Low lifetime stress exposure is associated with reduced stimulus–response memory
title_sort low lifetime stress exposure is associated with reduced stimulus–response memory
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362698/
https://www.ncbi.nlm.nih.gov/pubmed/28298555
http://dx.doi.org/10.1101/lm.045179.117
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