CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention

CYP1B1 gene single nucleotide polymorphisms G119T, C432G, and A453G were tested among 164 NSCLC patients treated by Video-Assisted Thoracoscopic Surgery. After a follow-up period of 5 years, it was found that CYP1B1 G119T mutant genotypes were related to a higher risk of tumor recurrence and death a...

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Autores principales: Li, Fengzhou, Zhang, Shaofeng, Zhang, Qi, Li, Jinxiu, Zhao, Shilei, Gu, Chundong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362720/
https://www.ncbi.nlm.nih.gov/pubmed/28377924
http://dx.doi.org/10.1155/2017/1529564
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author Li, Fengzhou
Zhang, Shaofeng
Zhang, Qi
Li, Jinxiu
Zhao, Shilei
Gu, Chundong
author_facet Li, Fengzhou
Zhang, Shaofeng
Zhang, Qi
Li, Jinxiu
Zhao, Shilei
Gu, Chundong
author_sort Li, Fengzhou
collection PubMed
description CYP1B1 gene single nucleotide polymorphisms G119T, C432G, and A453G were tested among 164 NSCLC patients treated by Video-Assisted Thoracoscopic Surgery. After a follow-up period of 5 years, it was found that CYP1B1 G119T mutant genotypes were related to a higher risk of tumor recurrence and death after surgical resection. However, C432G and A453G genotypes had no influence on long-term prognosis of the study cohort. Thus, G199T alleles are supposed to be an auxiliary predictor for prognosis of NSCLC patients and a potential target for precise drug intervention, as well as a candidate for further anticancer drug research.
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spelling pubmed-53627202017-04-04 CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention Li, Fengzhou Zhang, Shaofeng Zhang, Qi Li, Jinxiu Zhao, Shilei Gu, Chundong Biomed Res Int Research Article CYP1B1 gene single nucleotide polymorphisms G119T, C432G, and A453G were tested among 164 NSCLC patients treated by Video-Assisted Thoracoscopic Surgery. After a follow-up period of 5 years, it was found that CYP1B1 G119T mutant genotypes were related to a higher risk of tumor recurrence and death after surgical resection. However, C432G and A453G genotypes had no influence on long-term prognosis of the study cohort. Thus, G199T alleles are supposed to be an auxiliary predictor for prognosis of NSCLC patients and a potential target for precise drug intervention, as well as a candidate for further anticancer drug research. Hindawi 2017 2017-03-09 /pmc/articles/PMC5362720/ /pubmed/28377924 http://dx.doi.org/10.1155/2017/1529564 Text en Copyright © 2017 Fengzhou Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Fengzhou
Zhang, Shaofeng
Zhang, Qi
Li, Jinxiu
Zhao, Shilei
Gu, Chundong
CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention
title CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention
title_full CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention
title_fullStr CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention
title_full_unstemmed CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention
title_short CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention
title_sort cyp1b1 g199t polymorphism affects prognosis of nsclc patients with the potential to be an indicator and target for precise drug intervention
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362720/
https://www.ncbi.nlm.nih.gov/pubmed/28377924
http://dx.doi.org/10.1155/2017/1529564
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