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Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission?
Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Gastric Cancer Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362829/ https://www.ncbi.nlm.nih.gov/pubmed/28337358 http://dx.doi.org/10.5230/jgc.2017.17.e1 |
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author | Macedo, Filipa Ladeira, Kátia Longatto-Filho, Adhemar Martins, Sandra F. |
author_facet | Macedo, Filipa Ladeira, Kátia Longatto-Filho, Adhemar Martins, Sandra F. |
author_sort | Macedo, Filipa |
collection | PubMed |
description | Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search of the PubMed database was conducted with the MeSH terms: “Stomach neoplasms/blood [MeSH] or stomach neoplasms/blood supply [MeSH] and angiogenic proteins/blood [Major]”. A total of 30 articles were initially collected, and 4 were subsequently excluded. Among the 26 articles collected, 16 examined the role of vascular endothelial growth factor (VEGF), 4 studied endostatin, 3 investigated angiopoietin (Ang)-2, 2 studied the Ang-like protein 2 (ANGTPL2), and 1 each examined interleukin (IL)-12, IL-8, and hypoxia inducible factor. Regarding VEGF, 6 articles concluded that the protein was related to lymph node metastasis or distant metastases. Five articles concluded that VEGF levels were elevated in the presence of GC and decreased following tumor regression, suggesting that VEGF levels could be a predictor of recurrence. Four articles concluded that high VEGF levels were correlated with poor prognosis and lower survival rates. Ang-2 and ANGTPL2 were elevated in GC and associated with more aggressive disease. Endostatin was associated with intestinal GC. VEGF is the most extensively studied angiogenic factor. It is associated with the presence of neoplastic disease and lymph node metastasis. It appears to be a good biomarker for disease progression and remission, but not for diagnosis. The data regarding other biomarkers are inconclusive. |
format | Online Article Text |
id | pubmed-5362829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Gastric Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-53628292017-03-23 Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission? Macedo, Filipa Ladeira, Kátia Longatto-Filho, Adhemar Martins, Sandra F. J Gastric Cancer Review Article Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search of the PubMed database was conducted with the MeSH terms: “Stomach neoplasms/blood [MeSH] or stomach neoplasms/blood supply [MeSH] and angiogenic proteins/blood [Major]”. A total of 30 articles were initially collected, and 4 were subsequently excluded. Among the 26 articles collected, 16 examined the role of vascular endothelial growth factor (VEGF), 4 studied endostatin, 3 investigated angiopoietin (Ang)-2, 2 studied the Ang-like protein 2 (ANGTPL2), and 1 each examined interleukin (IL)-12, IL-8, and hypoxia inducible factor. Regarding VEGF, 6 articles concluded that the protein was related to lymph node metastasis or distant metastases. Five articles concluded that VEGF levels were elevated in the presence of GC and decreased following tumor regression, suggesting that VEGF levels could be a predictor of recurrence. Four articles concluded that high VEGF levels were correlated with poor prognosis and lower survival rates. Ang-2 and ANGTPL2 were elevated in GC and associated with more aggressive disease. Endostatin was associated with intestinal GC. VEGF is the most extensively studied angiogenic factor. It is associated with the presence of neoplastic disease and lymph node metastasis. It appears to be a good biomarker for disease progression and remission, but not for diagnosis. The data regarding other biomarkers are inconclusive. The Korean Gastric Cancer Association 2017-03 2017-03-13 /pmc/articles/PMC5362829/ /pubmed/28337358 http://dx.doi.org/10.5230/jgc.2017.17.e1 Text en Copyright © 2017. Korean Gastric Cancer Association https://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Macedo, Filipa Ladeira, Kátia Longatto-Filho, Adhemar Martins, Sandra F. Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission? |
title | Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission? |
title_full | Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission? |
title_fullStr | Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission? |
title_full_unstemmed | Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission? |
title_short | Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission? |
title_sort | gastric cancer and angiogenesis: is vegf a useful biomarker to assess progression and remission? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362829/ https://www.ncbi.nlm.nih.gov/pubmed/28337358 http://dx.doi.org/10.5230/jgc.2017.17.e1 |
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