Cargando…

Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat

CASE SUMMARY: A 15-year-old neutered female domestic shorthair cat presented with lethargy and acute-onset dyspnoea. Thoracic computed tomography (CT) revealed a large, cranial mediastinal mass with an estimated volume of 180.7 cm(3). Chemotherapy consisting of dexamethasone followed by L-asparagina...

Descripción completa

Detalles Bibliográficos
Autores principales: Tong, Linda J, Hosgood, Giselle, Labruyère, Julien, Bennett, Susan L, FitzGerald, Louise, Shiel, Robert E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362842/
https://www.ncbi.nlm.nih.gov/pubmed/28491357
http://dx.doi.org/10.1177/2055116915585024
Descripción
Sumario:CASE SUMMARY: A 15-year-old neutered female domestic shorthair cat presented with lethargy and acute-onset dyspnoea. Thoracic computed tomography (CT) revealed a large, cranial mediastinal mass with an estimated volume of 180.7 cm(3). Chemotherapy consisting of dexamethasone followed by L-asparaginase, prednisolone, vincristine and doxorubicin was commenced owing to the severity of disease and initial possibility of lymphoma. A diagnosis of lymphocyte-rich thymoma was made based upon histological examination, positive pancytokeratin staining, variable lymphocyte CD3 expression and T cell receptor gamma polyclonality. Thoracic CT performed 35 days after the commencement of chemotherapy showed a marked reduction in the size of the mass, with an estimated volume of 9.4 cm(3). A median sternotomy and thymectomy were performed. No clinical signs have recurred 34 months after surgery. CONCLUSIONS AND RELEVANCE: The response to chemotherapy in this case was unusual, and is likely associated with the high non-neoplastic lymphoid component of the mass. The case demonstrates that preoperative chemotherapy can be used to reduce thymoma volume prior to surgery, potentially decreasing anaesthetic risk.