Cargando…
Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat
CASE SUMMARY: A 15-year-old neutered female domestic shorthair cat presented with lethargy and acute-onset dyspnoea. Thoracic computed tomography (CT) revealed a large, cranial mediastinal mass with an estimated volume of 180.7 cm(3). Chemotherapy consisting of dexamethasone followed by L-asparagina...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362842/ https://www.ncbi.nlm.nih.gov/pubmed/28491357 http://dx.doi.org/10.1177/2055116915585024 |
_version_ | 1782517029160353792 |
---|---|
author | Tong, Linda J Hosgood, Giselle Labruyère, Julien Bennett, Susan L FitzGerald, Louise Shiel, Robert E |
author_facet | Tong, Linda J Hosgood, Giselle Labruyère, Julien Bennett, Susan L FitzGerald, Louise Shiel, Robert E |
author_sort | Tong, Linda J |
collection | PubMed |
description | CASE SUMMARY: A 15-year-old neutered female domestic shorthair cat presented with lethargy and acute-onset dyspnoea. Thoracic computed tomography (CT) revealed a large, cranial mediastinal mass with an estimated volume of 180.7 cm(3). Chemotherapy consisting of dexamethasone followed by L-asparaginase, prednisolone, vincristine and doxorubicin was commenced owing to the severity of disease and initial possibility of lymphoma. A diagnosis of lymphocyte-rich thymoma was made based upon histological examination, positive pancytokeratin staining, variable lymphocyte CD3 expression and T cell receptor gamma polyclonality. Thoracic CT performed 35 days after the commencement of chemotherapy showed a marked reduction in the size of the mass, with an estimated volume of 9.4 cm(3). A median sternotomy and thymectomy were performed. No clinical signs have recurred 34 months after surgery. CONCLUSIONS AND RELEVANCE: The response to chemotherapy in this case was unusual, and is likely associated with the high non-neoplastic lymphoid component of the mass. The case demonstrates that preoperative chemotherapy can be used to reduce thymoma volume prior to surgery, potentially decreasing anaesthetic risk. |
format | Online Article Text |
id | pubmed-5362842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-53628422017-05-10 Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat Tong, Linda J Hosgood, Giselle Labruyère, Julien Bennett, Susan L FitzGerald, Louise Shiel, Robert E JFMS Open Rep Case Report CASE SUMMARY: A 15-year-old neutered female domestic shorthair cat presented with lethargy and acute-onset dyspnoea. Thoracic computed tomography (CT) revealed a large, cranial mediastinal mass with an estimated volume of 180.7 cm(3). Chemotherapy consisting of dexamethasone followed by L-asparaginase, prednisolone, vincristine and doxorubicin was commenced owing to the severity of disease and initial possibility of lymphoma. A diagnosis of lymphocyte-rich thymoma was made based upon histological examination, positive pancytokeratin staining, variable lymphocyte CD3 expression and T cell receptor gamma polyclonality. Thoracic CT performed 35 days after the commencement of chemotherapy showed a marked reduction in the size of the mass, with an estimated volume of 9.4 cm(3). A median sternotomy and thymectomy were performed. No clinical signs have recurred 34 months after surgery. CONCLUSIONS AND RELEVANCE: The response to chemotherapy in this case was unusual, and is likely associated with the high non-neoplastic lymphoid component of the mass. The case demonstrates that preoperative chemotherapy can be used to reduce thymoma volume prior to surgery, potentially decreasing anaesthetic risk. SAGE Publications 2015-06-01 /pmc/articles/PMC5362842/ /pubmed/28491357 http://dx.doi.org/10.1177/2055116915585024 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm). |
spellingShingle | Case Report Tong, Linda J Hosgood, Giselle Labruyère, Julien Bennett, Susan L FitzGerald, Louise Shiel, Robert E Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat |
title | Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat |
title_full | Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat |
title_fullStr | Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat |
title_full_unstemmed | Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat |
title_short | Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat |
title_sort | marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362842/ https://www.ncbi.nlm.nih.gov/pubmed/28491357 http://dx.doi.org/10.1177/2055116915585024 |
work_keys_str_mv | AT tonglindaj markedcytoreductionofalymphocyterichmediastinalthymomawithneoadjuvantchemotherapyinacat AT hosgoodgiselle markedcytoreductionofalymphocyterichmediastinalthymomawithneoadjuvantchemotherapyinacat AT labruyerejulien markedcytoreductionofalymphocyterichmediastinalthymomawithneoadjuvantchemotherapyinacat AT bennettsusanl markedcytoreductionofalymphocyterichmediastinalthymomawithneoadjuvantchemotherapyinacat AT fitzgeraldlouise markedcytoreductionofalymphocyterichmediastinalthymomawithneoadjuvantchemotherapyinacat AT shielroberte markedcytoreductionofalymphocyterichmediastinalthymomawithneoadjuvantchemotherapyinacat |