Cargando…

Sinonasal aspergillosis in a British Shorthair cat in the UK

Case summary A 13-year-old, castrated male, British Shorthair cat presented for investigation of chronic, intermittent, bilateral epistaxis and stertor. CT revealed severe asymmetric bilateral intranasal involvement with extensive turbinate lysis, increased soft tissue attenuation and lysis of the s...

Descripción completa

Detalles Bibliográficos
Autores principales: Tamborini, Alice, Robertson, Elise, Talbot, Jessica J, Barrs, Vanessa R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362982/
https://www.ncbi.nlm.nih.gov/pubmed/28491427
http://dx.doi.org/10.1177/2055116916653775
_version_ 1782517083459813376
author Tamborini, Alice
Robertson, Elise
Talbot, Jessica J
Barrs, Vanessa R
author_facet Tamborini, Alice
Robertson, Elise
Talbot, Jessica J
Barrs, Vanessa R
author_sort Tamborini, Alice
collection PubMed
description Case summary A 13-year-old, castrated male, British Shorthair cat presented for investigation of chronic, intermittent, bilateral epistaxis and stertor. CT revealed severe asymmetric bilateral intranasal involvement with extensive turbinate lysis, increased soft tissue attenuation and lysis of the sphenopalatine bone and cribriform plate. On retroflexed pharyngoscopy, a plaque-like mass occluded the choanae. Rostral rhinoscopic examination revealed extensive loss of nasal turbinates, necrotic tissue and mucosal fungal plaques in the left nasal cavity. The right nasal cavity was less severely affected. The nasal cavities were debrided extensively of plaques and necrotic tissue. Aspergillus fumigatus was isolated on fungal culture, and species identity was confirmed using comparative sequence analysis of the partial β-tubulin gene. On histopathology of nasal biopsies, there was ulcerative lymphoplasmacytic and neutrophilic rhinitis, and fungal hyphae were identified on nasal mucosa, consistent with a non-invasive mycosis. The cat was treated with oral itraconazole after endoscopic debridement, but signs relapsed 4.5 months from diagnosis. Residual left nasal fungal plaques were again debrided endoscopically and oral posaconazole was administered for 6 months. Fourteen months from diagnosis, the cat remains clinically well with mild intermittent left nasal discharge secondary to atrophic rhinitis. Relevance and novel information This is the first case of rhinoscopically confirmed sinonasal aspergillosis to be diagnosed in a cat in the UK. Endoscopic confirmation of resolution of infection is useful in cases where mild nasal discharge persists after treatment.
format Online
Article
Text
id pubmed-5362982
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-53629822017-05-10 Sinonasal aspergillosis in a British Shorthair cat in the UK Tamborini, Alice Robertson, Elise Talbot, Jessica J Barrs, Vanessa R JFMS Open Rep Case Report Case summary A 13-year-old, castrated male, British Shorthair cat presented for investigation of chronic, intermittent, bilateral epistaxis and stertor. CT revealed severe asymmetric bilateral intranasal involvement with extensive turbinate lysis, increased soft tissue attenuation and lysis of the sphenopalatine bone and cribriform plate. On retroflexed pharyngoscopy, a plaque-like mass occluded the choanae. Rostral rhinoscopic examination revealed extensive loss of nasal turbinates, necrotic tissue and mucosal fungal plaques in the left nasal cavity. The right nasal cavity was less severely affected. The nasal cavities were debrided extensively of plaques and necrotic tissue. Aspergillus fumigatus was isolated on fungal culture, and species identity was confirmed using comparative sequence analysis of the partial β-tubulin gene. On histopathology of nasal biopsies, there was ulcerative lymphoplasmacytic and neutrophilic rhinitis, and fungal hyphae were identified on nasal mucosa, consistent with a non-invasive mycosis. The cat was treated with oral itraconazole after endoscopic debridement, but signs relapsed 4.5 months from diagnosis. Residual left nasal fungal plaques were again debrided endoscopically and oral posaconazole was administered for 6 months. Fourteen months from diagnosis, the cat remains clinically well with mild intermittent left nasal discharge secondary to atrophic rhinitis. Relevance and novel information This is the first case of rhinoscopically confirmed sinonasal aspergillosis to be diagnosed in a cat in the UK. Endoscopic confirmation of resolution of infection is useful in cases where mild nasal discharge persists after treatment. SAGE Publications 2016-06-12 /pmc/articles/PMC5362982/ /pubmed/28491427 http://dx.doi.org/10.1177/2055116916653775 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Tamborini, Alice
Robertson, Elise
Talbot, Jessica J
Barrs, Vanessa R
Sinonasal aspergillosis in a British Shorthair cat in the UK
title Sinonasal aspergillosis in a British Shorthair cat in the UK
title_full Sinonasal aspergillosis in a British Shorthair cat in the UK
title_fullStr Sinonasal aspergillosis in a British Shorthair cat in the UK
title_full_unstemmed Sinonasal aspergillosis in a British Shorthair cat in the UK
title_short Sinonasal aspergillosis in a British Shorthair cat in the UK
title_sort sinonasal aspergillosis in a british shorthair cat in the uk
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362982/
https://www.ncbi.nlm.nih.gov/pubmed/28491427
http://dx.doi.org/10.1177/2055116916653775
work_keys_str_mv AT tamborinialice sinonasalaspergillosisinabritishshorthaircatintheuk
AT robertsonelise sinonasalaspergillosisinabritishshorthaircatintheuk
AT talbotjessicaj sinonasalaspergillosisinabritishshorthaircatintheuk
AT barrsvanessar sinonasalaspergillosisinabritishshorthaircatintheuk