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Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

BACKGROUND: Normal myoepithelial cells (MECs) play an important tumour-suppressor role in the breast but display an altered phenotype in ductal carcinoma in situ (DCIS), gaining tumour-promoter functions. Matrix metalloproteinase-8 (MMP-8) is expressed by normal MECs but is lost in DCIS. This study...

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Detalles Bibliográficos
Autores principales:	Sarper, Muge, Allen, Michael D., Gomm, Jenny, Haywood, Linda, Decock, Julie, Thirkettle, Sally, Ustaoglu, Ahsen, Sarker, Shah-Jalal, Marshall, John, Edwards, Dylan R., Jones, J. Louise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363009/ https://www.ncbi.nlm.nih.gov/pubmed/28330493 http://dx.doi.org/10.1186/s13058-017-0822-9

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