Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis

Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly, but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca(2+)) homeostasis can exacerbate many of the factors proposed to mediate muscle degeneration in IBM, such as mitochondrial dysfunction,...

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Detalles Bibliográficos
Autores principales: Amici, David R., Pinal-Fernandez, Iago, Mázala, Davi A. G., Lloyd, Thomas E., Corse, Andrea M., Christopher-Stine, Lisa, Mammen, Andrew L., Chin, Eva R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363023/
https://www.ncbi.nlm.nih.gov/pubmed/28330496
http://dx.doi.org/10.1186/s40478-017-0427-7

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