Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases

Nucleoside reverse transcriptase (RT) inhibitors constitute the backbone of current therapies against human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2, respectively). However, mutational pathways leading to the development of nucleoside analogue resistance are different in both types...

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Detalles Bibliográficos
Autores principales: Álvarez, Mar, Sebastián-Martín, Alba, García-Marquina, Guillermo, Menéndez-Arias, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363063/
https://www.ncbi.nlm.nih.gov/pubmed/28333133
http://dx.doi.org/10.1038/srep44834

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