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The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology

The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d‐negative antibody‐mediated rejection (ABMR) from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor‐specific an...

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Autores principales: Loupy, A., Haas, M., Solez, K., Racusen, L., Glotz, D., Seron, D., Nankivell, B. J., Colvin, R. B., Afrouzian, M., Akalin, E., Alachkar, N., Bagnasco, S., Becker, J. U., Cornell, L., Drachenberg, C., Dragun, D., de Kort, H., Gibson, I. W., Kraus, E. S., Lefaucheur, C., Legendre, C., Liapis, H., Muthukumar, T., Nickeleit, V., Orandi, B., Park, W., Rabant, M., Randhawa, P., Reed, E. F., Roufosse, C., Seshan, S. V., Sis, B., Singh, H. K., Schinstock, C., Tambur, A., Zeevi, A., Mengel, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363228/
https://www.ncbi.nlm.nih.gov/pubmed/27862883
http://dx.doi.org/10.1111/ajt.14107
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author Loupy, A.
Haas, M.
Solez, K.
Racusen, L.
Glotz, D.
Seron, D.
Nankivell, B. J.
Colvin, R. B.
Afrouzian, M.
Akalin, E.
Alachkar, N.
Bagnasco, S.
Becker, J. U.
Cornell, L.
Drachenberg, C.
Dragun, D.
de Kort, H.
Gibson, I. W.
Kraus, E. S.
Lefaucheur, C.
Legendre, C.
Liapis, H.
Muthukumar, T.
Nickeleit, V.
Orandi, B.
Park, W.
Rabant, M.
Randhawa, P.
Reed, E. F.
Roufosse, C.
Seshan, S. V.
Sis, B.
Singh, H. K.
Schinstock, C.
Tambur, A.
Zeevi, A.
Mengel, M.
author_facet Loupy, A.
Haas, M.
Solez, K.
Racusen, L.
Glotz, D.
Seron, D.
Nankivell, B. J.
Colvin, R. B.
Afrouzian, M.
Akalin, E.
Alachkar, N.
Bagnasco, S.
Becker, J. U.
Cornell, L.
Drachenberg, C.
Dragun, D.
de Kort, H.
Gibson, I. W.
Kraus, E. S.
Lefaucheur, C.
Legendre, C.
Liapis, H.
Muthukumar, T.
Nickeleit, V.
Orandi, B.
Park, W.
Rabant, M.
Randhawa, P.
Reed, E. F.
Roufosse, C.
Seshan, S. V.
Sis, B.
Singh, H. K.
Schinstock, C.
Tambur, A.
Zeevi, A.
Mengel, M.
author_sort Loupy, A.
collection PubMed
description The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d‐negative antibody‐mediated rejection (ABMR) from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor‐specific antibody tests (anti‐HLA and non‐HLA) with transplant histopathology, and questions of molecular transplant diagnostics. The use of transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement the diagnosis and classification of rejection requires further consensus agreement and validation in biopsies. Newly introduced concepts include the i‐IFTA score, comprising inflammation within areas of fibrosis and atrophy and acceptance of transplant arteriolopathy within the descriptions of chronic active T cell–mediated rejection (TCMR) or chronic ABMR. The pattern of mixed TCMR and ABMR was increasingly recognized. This report also includes improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification. The goal of the Banff process is ongoing integration of advances in histologic, serologic, and molecular diagnostic techniques to produce a consensus‐based reporting system that offers precise composite scores, accurate routine diagnostics, and applicability to next‐generation clinical trials.
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spelling pubmed-53632282017-04-06 The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology Loupy, A. Haas, M. Solez, K. Racusen, L. Glotz, D. Seron, D. Nankivell, B. J. Colvin, R. B. Afrouzian, M. Akalin, E. Alachkar, N. Bagnasco, S. Becker, J. U. Cornell, L. Drachenberg, C. Dragun, D. de Kort, H. Gibson, I. W. Kraus, E. S. Lefaucheur, C. Legendre, C. Liapis, H. Muthukumar, T. Nickeleit, V. Orandi, B. Park, W. Rabant, M. Randhawa, P. Reed, E. F. Roufosse, C. Seshan, S. V. Sis, B. Singh, H. K. Schinstock, C. Tambur, A. Zeevi, A. Mengel, M. Am J Transplant Meeting Reports The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d‐negative antibody‐mediated rejection (ABMR) from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor‐specific antibody tests (anti‐HLA and non‐HLA) with transplant histopathology, and questions of molecular transplant diagnostics. The use of transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement the diagnosis and classification of rejection requires further consensus agreement and validation in biopsies. Newly introduced concepts include the i‐IFTA score, comprising inflammation within areas of fibrosis and atrophy and acceptance of transplant arteriolopathy within the descriptions of chronic active T cell–mediated rejection (TCMR) or chronic ABMR. The pattern of mixed TCMR and ABMR was increasingly recognized. This report also includes improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification. The goal of the Banff process is ongoing integration of advances in histologic, serologic, and molecular diagnostic techniques to produce a consensus‐based reporting system that offers precise composite scores, accurate routine diagnostics, and applicability to next‐generation clinical trials. John Wiley and Sons Inc. 2016-12-28 2017-01 /pmc/articles/PMC5363228/ /pubmed/27862883 http://dx.doi.org/10.1111/ajt.14107 Text en © 2016 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of American Society of Transplant Surgeons This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Meeting Reports
Loupy, A.
Haas, M.
Solez, K.
Racusen, L.
Glotz, D.
Seron, D.
Nankivell, B. J.
Colvin, R. B.
Afrouzian, M.
Akalin, E.
Alachkar, N.
Bagnasco, S.
Becker, J. U.
Cornell, L.
Drachenberg, C.
Dragun, D.
de Kort, H.
Gibson, I. W.
Kraus, E. S.
Lefaucheur, C.
Legendre, C.
Liapis, H.
Muthukumar, T.
Nickeleit, V.
Orandi, B.
Park, W.
Rabant, M.
Randhawa, P.
Reed, E. F.
Roufosse, C.
Seshan, S. V.
Sis, B.
Singh, H. K.
Schinstock, C.
Tambur, A.
Zeevi, A.
Mengel, M.
The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology
title The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology
title_full The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology
title_fullStr The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology
title_full_unstemmed The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology
title_short The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology
title_sort banff 2015 kidney meeting report: current challenges in rejection classification and prospects for adopting molecular pathology
topic Meeting Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363228/
https://www.ncbi.nlm.nih.gov/pubmed/27862883
http://dx.doi.org/10.1111/ajt.14107
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