Rapid and Complete Surface Modification with Strain‐Promoted Oxidation‐Controlled Cyclooctyne‐1,2‐Quinone Cycloaddition (SPOCQ)

Strain‐promoted oxidation‐controlled cyclooctyne‐1,2‐quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non‐4‐yne (BCN) and surface‐bound quinones revealed an unprecedented 100 % conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART‐M...

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Detalles Bibliográficos
Autores principales: Sen, Rickdeb, Escorihuela, Jorge, van Delft, Floris, Zuilhof, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363232/
https://www.ncbi.nlm.nih.gov/pubmed/28198134
http://dx.doi.org/10.1002/anie.201612037
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author Sen, Rickdeb
Escorihuela, Jorge
van Delft, Floris
Zuilhof, Han
author_facet Sen, Rickdeb
Escorihuela, Jorge
van Delft, Floris
Zuilhof, Han
author_sort Sen, Rickdeb
collection PubMed
description Strain‐promoted oxidation‐controlled cyclooctyne‐1,2‐quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non‐4‐yne (BCN) and surface‐bound quinones revealed an unprecedented 100 % conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART‐MS) revealed the underlying kinetics and activation parameters of this immobilization process in dependence on its microenvironment.
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spelling pubmed-53632322017-04-06 Rapid and Complete Surface Modification with Strain‐Promoted Oxidation‐Controlled Cyclooctyne‐1,2‐Quinone Cycloaddition (SPOCQ) Sen, Rickdeb Escorihuela, Jorge van Delft, Floris Zuilhof, Han Angew Chem Int Ed Engl Communications Strain‐promoted oxidation‐controlled cyclooctyne‐1,2‐quinone cycloaddition (SPOCQ) between functionalized bicyclo[6.1.0]non‐4‐yne (BCN) and surface‐bound quinones revealed an unprecedented 100 % conjugation efficiency. In addition, monitoring by direct analysis in real time mass spectrometry (DART‐MS) revealed the underlying kinetics and activation parameters of this immobilization process in dependence on its microenvironment. John Wiley and Sons Inc. 2017-02-15 2017-03-13 /pmc/articles/PMC5363232/ /pubmed/28198134 http://dx.doi.org/10.1002/anie.201612037 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Sen, Rickdeb
Escorihuela, Jorge
van Delft, Floris
Zuilhof, Han
Rapid and Complete Surface Modification with Strain‐Promoted Oxidation‐Controlled Cyclooctyne‐1,2‐Quinone Cycloaddition (SPOCQ)
title Rapid and Complete Surface Modification with Strain‐Promoted Oxidation‐Controlled Cyclooctyne‐1,2‐Quinone Cycloaddition (SPOCQ)
title_full Rapid and Complete Surface Modification with Strain‐Promoted Oxidation‐Controlled Cyclooctyne‐1,2‐Quinone Cycloaddition (SPOCQ)
title_fullStr Rapid and Complete Surface Modification with Strain‐Promoted Oxidation‐Controlled Cyclooctyne‐1,2‐Quinone Cycloaddition (SPOCQ)
title_full_unstemmed Rapid and Complete Surface Modification with Strain‐Promoted Oxidation‐Controlled Cyclooctyne‐1,2‐Quinone Cycloaddition (SPOCQ)
title_short Rapid and Complete Surface Modification with Strain‐Promoted Oxidation‐Controlled Cyclooctyne‐1,2‐Quinone Cycloaddition (SPOCQ)
title_sort rapid and complete surface modification with strain‐promoted oxidation‐controlled cyclooctyne‐1,2‐quinone cycloaddition (spocq)
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363232/
https://www.ncbi.nlm.nih.gov/pubmed/28198134
http://dx.doi.org/10.1002/anie.201612037
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AT vandelftfloris rapidandcompletesurfacemodificationwithstrainpromotedoxidationcontrolledcyclooctyne12quinonecycloadditionspocq
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